Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of programmed cell death protein 4, Pdcd4, in a human endocrine pancreatic cell line Bon-1 decreases levels of dUTPase, but does not in colon carcinoma cell line HCT116, treatment of a human breast adenocarcinoma cell line MCF-7, with 5-fluorouracil results in regulated expression of Pdcd4 and dUTPase, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | programmed cell death protein 4 downregulates dUTPase in certain cell types, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? | |
additional information | Homo sapiens | overexpression of dUTPase is associated with resistance to chemotherapeutic agents targeting thymidilate biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BON-1 cell | an endocrine pancreatic cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
additional information | overexpression of dUTPase is associated with resistance to chemotherapeutic agents targeting thymidilate biosynthesis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dUTPase | - |
Homo sapiens |