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Literature summary for 3.6.1.23 extracted from

  • Takacs, E.; Grolmusz, V.K.; Vertessy, B.G.
    A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases (2004), FEBS Lett., 566, 48-54.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Drosophila melanogaster
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Drosophila melanogaster removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
?
dUTP + H2O Escherichia coli removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
Drosophila melanogaster dUMP + diphosphate
-
?
dUTP + H2O
-
Escherichia coli dUMP + diphosphate
-
?
dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Drosophila melanogaster dUMP + diphosphate
-
?
dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Escherichia coli dUMP + diphosphate
-
?

Subunits

Subunits Comment Organism
trimer
-
Drosophila melanogaster
trimer
-
Escherichia coli

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
53
-
melting point, increases in the presence of Mg2+ and substrate Drosophila melanogaster
74.5
-
melting point Escherichia coli