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Literature summary for 3.6.1.23 extracted from

  • Ingraham, H.A.; Goulian, M.
    Deoxyuridine triphosphatase: a potential site of interaction with pyrimidine nucleotide analogues (1982), Biochem. Biophys. Res. Commun., 109, 746-752.
    View publication on PubMed
Search for more literature for 3.6.1.23

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 50 mM, 30% inhibition Homo sapiens
Cu2+
-
 Homo sapiens
EDTA 0.5 mM, more than 90% inhibition Homo sapiens
EGTA 10 mM, more than 90% inhibition Homo sapiens
Mn2+
-
 Homo sapiens
Zn2+
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
 dUTP
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
KB cell
-
 Homo sapiens
-
lymphoid tissue
-
 Homo sapiens
-
RAJI cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.7
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-dideoxyUTP + H2O 76% of the activity with dUTP Homo sapiens 2',3'-dideoxy-UMP + diphosphate
-
 ?
6-azaUTP + H2O 39% of the activity with dUTP Homo sapiens 6-azaUMP + diphosphate
-
 ?
araUTP + H2O 90% of the activity with dUTP Homo sapiens araUMP + diphosphate
-
 ?
dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 9
-
 Homo sapiens