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Literature summary for 3.6.1.23 extracted from

  • Hokari, S.; Sakagishi, Y.; Tsukada, K.
    Enhanced activity of deoxyuridine 5'-triphosphatase in regenerating rat liver (1982), Biochem. Biophys. Res. Commun., 108, 95-101.
    View publication on PubMed
Search for more literature for 3.6.1.23

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ 5 mM, 69% inhibition Rattus norvegicus
EDTA 1 mM, 91% inhibition Rattus norvegicus
Mn2+ 5 mM, 26% inhibition Rattus norvegicus
Zn2+ 5 mM, 23% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 dUTP
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ enhances activity Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver regenerating, activity in rat liver begins to rise 16 h after partial hepatectomy and reaches a maximum about 24 h after the operation, rising to at least 5 to 6 times the normal level Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Rattus norvegicus dUMP + diphosphate
-
 ?
UTP + H2O at about 3% of the activity with dUTP Rattus norvegicus UMP + diphosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 broad plateau Rattus norvegicus