Literature summary for 3.6.1.22 extracted from

AbdelRaheim, S.R.; Cartwright, J.L.; Gasmi, L.; McLennan, A.G.
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes (2001), Arch. Biochem. Biophys., 388, 18-24.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.17	-	NADH	pH 7.7, 37°C	Saccharomyces cerevisiae
0.5	-	NAD+	pH 7.7, 37°C	Saccharomyces cerevisiae
1.3	-	ADP-ribose	pH 7.7, 37°C	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Saccharomyces cerevisiae	5777	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	enzyme may work in the regulation of nicotinamide coenzyme concentration in the peroxisome	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P53164	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	protein has a potential peroxisomal targeting signal	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP-ribose + H2O	-	Saccharomyces cerevisiae	?	-	?
diadenosine diphosphate + H2O	-	Saccharomyces cerevisiae	?	-	?
additional information	enzyme may work in the regulation of nicotinamide coenzyme concentration in the peroxisome	Saccharomyces cerevisiae	?	-	?
NAD+ + H2O	-	Saccharomyces cerevisiae	NMN + AMP	-	?
NADH + H2O	-	Saccharomyces cerevisiae	NMNH + AMP	-	?
NADP+ + H2O	-	Saccharomyces cerevisiae	? + AMP	-	?
NADPH + H2O	-	Saccharomyces cerevisiae	NMNH + AMP	-	?

Synonyms

Synonyms	Comment	Organism
NPY1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)