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Literature summary for 3.6.1.21 extracted from
- Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor (1967), J. Biol. Chem., 242, 1944-1954.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.9 | - |
ADP-glucose | - |
Salmonella enterica subsp. enterica serovar Typhimurium |  |
| 40 | - |
GDP-Man | same Km for GDP-Glc and GDP-Man | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 40 | - |
GDP-Glc | same Km for GDP-Glc and GDP-Man | Salmonella enterica subsp. enterica serovar Typhimurium | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
| soluble | - |
Escherichia coli | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| Mg2+ | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-sugar + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
AMP + sugar phosphate | - |
? | |
| ADP-sugar + H2O | Escherichia coli | - |
AMP + sugar phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
strain ATCC 12793 | - |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial purification together with UDP-sugar pyrophosphatase | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP-glucose + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | AMP + alpha-D-glucose 1-phosphate | - |
? | |
| ADP-sugar + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | AMP + sugar phosphate | - |
? | |
| ADP-sugar + H2O | - |
Escherichia coli | AMP + sugar phosphate | - |
? | |
| GDP-Glc + H2O | very poor substrate | Salmonella enterica subsp. enterica serovar Typhimurium | GMP + Glc-1-phosphate | - |
? | |
| GDP-Man + H2O | very poor substrate | Salmonella enterica subsp. enterica serovar Typhimurium | GMP + Man-1-phosphate | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
no activity even in presence of Mg2+ or Co2+ | Escherichia coli |
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