BRENDA - Enzyme Database
show all sequences of 3.6.1.17

Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability

Arczewska, K.D.; Baumeier, C.; Kassahun, H.; Sengupta, T.; Bjoras, M.; Kusmierek, J.T.; Nilsen, H.; DNA Repair 10, 176-187 (2011)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Escherichia coli BL21(DE3)T cells
Caenorhabditis elegans
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.007
-
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.0986
-
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.1143
-
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.182
-
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.3846
-
2-oxo-dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
Organism
Organism
UniProt
Commentary
Textmining
Caenorhabditis elegans
Q9U2M7
-
-
Caenorhabditis elegans Bristol N2
Q9U2M7
-
-
Purification (Commentary)
Purification (Commentary)
Organism
HisTrap FF column chromatography and Superdex 75 gel filtration
Caenorhabditis elegans
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2-oxo-dATP + H2O
less efficient hydrolysis compared to 8-oxo-dGTP
719339
Caenorhabditis elegans
?
-
-
-
?
2-oxo-dATP + H2O
less efficient hydrolysis compared to 8-oxo-dGTP
719339
Caenorhabditis elegans Bristol N2
?
-
-
-
?
8-oxo-dGTP + H2O
the enzyme does not show a strong preference for 8-oxo-dGTP and is able to hydrolyze unmodified dATP and dGTP with comparable efficiency
719339
Caenorhabditis elegans
8-oxo-dGMP + diphosphate
-
-
-
?
8-oxo-dGTP + H2O
the enzyme does not show a strong preference for 8-oxo-dGTP and is able to hydrolyze unmodified dATP and dGTP with comparable efficiency
719339
Caenorhabditis elegans Bristol N2
8-oxo-dGMP + diphosphate
-
-
-
?
dATP + H2O
-
719339
Caenorhabditis elegans
?
-
-
-
?
dATP + H2O
-
719339
Caenorhabditis elegans Bristol N2
?
-
-
-
?
dGTP + H2O
-
719339
Caenorhabditis elegans
?
-
-
-
?
dGTP + H2O
-
719339
Caenorhabditis elegans Bristol N2
?
-
-
-
?
diadenosine 5',5''''-P1,P4-tetraphosphate + H2O
-
719339
Caenorhabditis elegans
AMP + ATP
-
-
-
?
diadenosine 5',5''''-P1,P4-tetraphosphate + H2O
-
719339
Caenorhabditis elegans Bristol N2
AMP + ATP
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
NDX-4
-
Caenorhabditis elegans
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.37
-
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.51
-
2-oxo-dATP
in 5 0mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.53
-
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.58
-
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
27
-
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli BL21(DE3)T cells
Caenorhabditis elegans
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.007
-
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.0986
-
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.1143
-
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.182
-
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.3846
-
2-oxo-dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
Purification (Commentary) (protein specific)
Commentary
Organism
HisTrap FF column chromatography and Superdex 75 gel filtration
Caenorhabditis elegans
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2-oxo-dATP + H2O
less efficient hydrolysis compared to 8-oxo-dGTP
719339
Caenorhabditis elegans
?
-
-
-
?
2-oxo-dATP + H2O
less efficient hydrolysis compared to 8-oxo-dGTP
719339
Caenorhabditis elegans Bristol N2
?
-
-
-
?
8-oxo-dGTP + H2O
the enzyme does not show a strong preference for 8-oxo-dGTP and is able to hydrolyze unmodified dATP and dGTP with comparable efficiency
719339
Caenorhabditis elegans
8-oxo-dGMP + diphosphate
-
-
-
?
8-oxo-dGTP + H2O
the enzyme does not show a strong preference for 8-oxo-dGTP and is able to hydrolyze unmodified dATP and dGTP with comparable efficiency
719339
Caenorhabditis elegans Bristol N2
8-oxo-dGMP + diphosphate
-
-
-
?
dATP + H2O
-
719339
Caenorhabditis elegans
?
-
-
-
?
dATP + H2O
-
719339
Caenorhabditis elegans Bristol N2
?
-
-
-
?
dGTP + H2O
-
719339
Caenorhabditis elegans
?
-
-
-
?
dGTP + H2O
-
719339
Caenorhabditis elegans Bristol N2
?
-
-
-
?
diadenosine 5',5''''-P1,P4-tetraphosphate + H2O
-
719339
Caenorhabditis elegans
AMP + ATP
-
-
-
?
diadenosine 5',5''''-P1,P4-tetraphosphate + H2O
-
719339
Caenorhabditis elegans Bristol N2
AMP + ATP
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.37
-
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.51
-
2-oxo-dATP
in 5 0mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.53
-
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
0.58
-
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
27
-
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
General Information
General Information
Commentary
Organism
malfunction
loss of NDX-4 leads to upregulation of key stress responsive genes that likely compensate for the in vivo role of NDX-4 in protection against deleterious consequences of oxidative stress. NDX-4 deficiency protects nematodes from acute heat shock
Caenorhabditis elegans
physiological function
the enzyme contributes to genomic stability in vivo in Caenorhabditis elegans
Caenorhabditis elegans
General Information (protein specific)
General Information
Commentary
Organism
malfunction
loss of NDX-4 leads to upregulation of key stress responsive genes that likely compensate for the in vivo role of NDX-4 in protection against deleterious consequences of oxidative stress. NDX-4 deficiency protects nematodes from acute heat shock
Caenorhabditis elegans
physiological function
the enzyme contributes to genomic stability in vivo in Caenorhabditis elegans
Caenorhabditis elegans
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.3
-
2-oxo-dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
2.9
-
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
3.3
-
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
5.9
-
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
3900
-
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
1.3
-
2-oxo-dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
2.9
-
dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
3.3
-
dATP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
5.9
-
8-oxo-dGTP
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
3900
-
diadenosine 5',5''''-P1,P4-tetraphosphate
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
Caenorhabditis elegans
Other publictions for EC 3.6.1.17
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733091
Wu
Elucidating diphosphoinositol ...
Homo sapiens
Angew. Chem. Int. Ed. Engl.
53
7192-7197
2014
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733346
Barta
Chlamydia trachomatis CT771 (n ...
Chlamydia trachomatis
Biochemistry
53
214-224
2014
-
-
-
1
-
-
-
6
-
2
-
-
-
6
-
-
-
-
-
-
-
-
1
-
2
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
6
6
733872
Sasaki
Enzymatic characteristics of a ...
Myxococcus xanthus, Myxococcus xanthus DK 1622
FEBS Lett.
588
3395-3402
2014
-
-
-
-
-
-
5
2
-
2
-
-
-
2
-
-
-
-
-
-
-
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
2
-
2
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
733257
Ge
Crystal structure of wild-type ...
Homo sapiens
Biochem. Biophys. Res. Commun.
432
16-21
2013
-
-
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
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-
-
-
-
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-
-
1
1
-
-
-
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733450
Osman
Molecular characterization and ...
Plasmodium falciparum
Biol. Pharm. Bull.
35
1191-1196
2012
-
-
1
-
2
-
-
3
-
5
1
-
-
4
-
-
-
-
-
-
-
-
2
1
1
1
-
1
3
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
3
-
5
1
-
-
-
-
-
-
-
-
-
2
1
1
-
1
3
1
-
-
-
-
-
-
-
-
-
733563
Albright
NPP4 is a procoagulant enzyme ...
Homo sapiens
Blood
120
4432-4440
2012
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
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-
1
-
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2
-
1
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1
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1
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
719339
Arczewska
Caenorhabditis elegans NDX-4 i ...
Caenorhabditis elegans, Caenorhabditis elegans Bristol N2
DNA Repair
10
176-187
2011
-
-
1
-
-
-
-
5
-
-
-
-
-
6
-
-
1
-
-
-
-
-
10
-
1
-
-
-
5
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
1
-
-
-
-
10
-
-
-
-
5
-
-
-
-
-
2
2
-
5
5
710715
Jeyakanthan
Free and ATP-bound structures ...
Aquifex aeolicus
Acta Crystallogr. Sect. D
66
116-124
2010
-
-
1
1
-
-
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
3
-
4
-
-
-
3
-
-
-
-
-
-
-
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-
1
-
1
-
-
-
-
-
3
-
-
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-
-
-
-
1
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
-
3
3
713580
Vasilenko
SARS coronavirus protein 7a in ...
Homo sapiens
Virol. J.
7
31
2010
-
-
-
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
1
-
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1
-
2
-
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-
-
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1
-
-
1
-
-
-
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
697896
Guranowski
Novel diadenosine polyphosphat ...
Homo sapiens, Lupinus angustifolius
FEBS J.
276
1546-1553
2009
-
-
-
-
-
-
4
2
-
2
-
2
-
4
-
-
1
-
-
-
-
-
6
-
4
2
-
-
-
2
-
-
-
4
-
-
-
-
-
-
-
-
-
-
4
4
2
-
2
-
2
-
-
-
1
-
-
-
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
711209
Branson
Discovery of inhibitors of lup ...
Lupinus angustifolius
Biochemistry
48
7614-7620
2009
-
-
-
-
-
-
7
-
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1
-
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1
-
2
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3
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7
3
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-
1
-
-
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-
-
-
-
-
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-
-
-
-
695301
Szurmak
A diadenosine 5',5''-P1P4 tetr ...
Arabidopsis thaliana
Acta Biochim. Pol.
55
151-160
2008
-
-
1
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Swarbrick
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Guranowski
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Lazewska
Human placental (asymmetrical) ...
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Robinson
Isolation and charcterization ...
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Dinucleoside tetraphosphatase ...
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Cameselle
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Cameselle
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Moreno
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Cameselle
Bis-(5-guanosyl) tetraphosphat ...
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Vallejo
Dinucleosidasetetraphosphatase ...
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Lobaton
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Vallejo
Diguanosinetetraphosphate guan ...
Artemia salina
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Warner
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2
-
1
-
1
-
-
-
-
-
-
-