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Literature summary for 3.6.1.17 extracted from

  • Guranowski, A.; Starzynska, E.; McLennan, A.G.; Baraniak, J.; Stec, W.J.
    Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases (2003), Biochem. J., 373, 635-640.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.17

Inhibitors

Inhibitors Comment Organism Structure
1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol
-
 Homo sapiens
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
 Homo sapiens
1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol
-
 Lupinus angustifolius
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
 Homo sapiens
1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol
-
 Lupinus angustifolius
1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol
-
 Homo sapiens
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
 Homo sapiens
1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol
-
 Lupinus angustifolius
1,3-di(adenosine-5'-O-phospho)glycerol
-
 Homo sapiens
1,4-di(adenosine-5'-O-phospho)erythritol
-
 Homo sapiens
1,4-di(adenosine-5'-O-phospho)erythritol
-
 Lupinus angustifolius
1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
 Homo sapiens
1,4-di(adenosine-5'-O-phosphorothio)erythritol
-
 Lupinus angustifolius
di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Lupinus angustifolius
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Homo sapiens ATP + AMP
-
 ?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Lupinus angustifolius ATP + AMP
-
 ?

Synonyms

Synonyms Comment Organism
(asymmetrical) dinucleoside tetraphosphatase
-
 Homo sapiens
(asymmetrical) dinucleoside tetraphosphatase
-
 Lupinus angustifolius
Ap4A hydrolase
-
 Homo sapiens
Ap4A hydrolase
-
 Lupinus angustifolius

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00015
-
 1,4-di(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Lupinus angustifolius
0.0015
-
 1,4-di(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Homo sapiens
0.0037
-
 di(adenosine-5'-O-phosphorothio)-di(adenosine-5'-phospho)pentaerythritol pH 7.6, 30°C Homo sapiens
0.0085
-
 1,4-di(adenosine-5'-O-phospho)erythritol pH 7.6, 30°C Lupinus angustifolius
0.013
-
 1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Lupinus angustifolius
0.017
-
 1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol pH 7.6, 30°C Lupinus angustifolius
0.018
-
 1,2,3,4-tetra(adenosine-5'-O-phosphorothio)erythritol pH 7.6, 30°C Homo sapiens
0.025
-
 1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol pH 7.6, 30°C Lupinus angustifolius
0.031
-
 1,2,3,4-tetra(adenosine-5'-O-phospho)erythritol pH 7.6, 30°C Homo sapiens
0.032
-
 1,3-di(adenosine-5'-O-phospho)-2-phosphorothio-glycerol pH 7.6, 30°C Homo sapiens
0.037
-
 1,2,3-tri(adenosine-5'-O-phosphorothio)glycerol pH 7.6, 30°C Homo sapiens
0.066
-
 1,3-di(adenosine-5'-O-phospho)-2-phospho-glycerol pH 7.6, 30°C Homo sapiens
0.109
-
 1,3-di(adenosine-5'-O-phospho)glycerol pH 7.6, 30°C Homo sapiens
0.142
-
 1,4-di(adenosine-5'-O-phospho)erythritol pH 7.6, 30°C Homo sapiens