BRENDA - Enzyme Database show
show all sequences of 3.6.1.14

Synthesis and degradation of adenosine 5-tetraphosphate by nicotinamide and nicotinate phosphoribosyltransferases

Amici, A.; Grolla, A.A.; Del Grosso, E.; Bellini, R.; Bianchi, M.; Travelli, C.; Garavaglia, S.; Sorci, L.; Raffaelli, N.; Ruggieri, S.; Genazzani, A.A.; Orsomando, G.; Cell Chem. Biol. 24, 553-564 (2017)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
H213A
mutant is unable to generate adenosine 5'-tetraphosphate
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + phosphate
enzyme nicotinate phosphoribosyltransferase, EC 6.3.4.21, is able to generate adenosine 5'-tetraphosphate using substrate ATP and product phosphate. Accompanying a typically irreversible hydrolysis of ATP to ADP and phosphate, is a fully reversible phosphate transfer reaction between ATP and adenosine 5'-tetraphosphate
744647
Homo sapiens
adenosine 5'-tetraphosphate + H2O
-
-
-
-
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H213A
mutant is unable to generate adenosine 5'-tetraphosphate
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + phosphate
enzyme nicotinate phosphoribosyltransferase, EC 6.3.4.21, is able to generate adenosine 5'-tetraphosphate using substrate ATP and product phosphate. Accompanying a typically irreversible hydrolysis of ATP to ADP and phosphate, is a fully reversible phosphate transfer reaction between ATP and adenosine 5'-tetraphosphate
744647
Homo sapiens
adenosine 5'-tetraphosphate + H2O
-
-
-
-
Other publictions for EC 3.6.1.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744647
Amici
Synthesis and degradation of ...
Homo sapiens
Cell Chem. Biol.
24
553-564
2017
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668579
Guranowski
Methylene analogues of adenosi ...
Homo sapiens, Lupinus luteus
FEBS J.
273
829-838
2006
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209852
Guranowski
Adenosine 5'-tetraphosphate ph ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1380
232-238
1998
-
-
-
-
-
-
3
1
-
4
1
-
-
3
-
-
-
-
-
-
-
-
4
1
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
4
1
-
-
-
-
-
-
-
-
-
4
1
-
-
-
2
1
1
-
-
-
-
-
-
-
-
209873
Guranowski
Adenosine 5'-tetraphosphate ph ...
Lupinus luteus
Biochem. J.
328
257-262
1997
-
-
-
-
-
-
3
1
-
4
1
-
-
1
-
-
1
-
-
1
1
1
5
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
4
1
-
-
-
-
1
-
1
1
1
5
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
209871
Small
Purification and properties of ...
Oryctolagus cuniculus
Biochemistry
5
14-26
1966
-
-
-
-
-
-
3
2
-
5
-
-
-
1
-
-
1
-
-
4
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
-
5
-
-
-
-
-
1
-
4
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-