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Literature summary for 3.6.1.13 extracted from

  • Rafty, L.A.; Schmidt, M.T.; Perraud, A.L.; Scharenberg, A.M.; Denu, J.M.
    Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases (2002), J. Biol. Chem., 277, 47114-47122.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
2''-O-acetyl-ADP-ribose at pH 7.5 and 37°C Mus musculus
0.048
-
ADP-D-ribose at pH 7.5 and 37°C Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-D-ribose + H2O Mus musculus
-
AMP + D-ribose 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NIH-3T3 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2''-O-acetyl-ADP-ribose + H2O
-
Mus musculus AMP + 2-O-acetyl-D-ribose 5-phosphate
-
?
ADP-D-ribose + H2O
-
Mus musculus AMP + D-ribose 5-phosphate
-
?

Synonyms

Synonyms Comment Organism
ADP-ribose hydrolase
-
Mus musculus
NUDT5
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.78
-
2''-O-acetyl-ADP-ribose at pH 7.5 and 37°C Mus musculus
0.94
-
ADP-D-ribose at pH 7.5 and 37°C Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
17.3
-
2''-O-acetyl-ADP-ribose at pH 7.5 and 37°C Mus musculus
19.6
-
ADP-D-ribose at pH 7.5 and 37°C Mus musculus