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Literature summary for 3.6.1.12 extracted from

  • Llona-Minguez, S.; Hoeglund, A.; Ghassemian, A.; Desroses, M.; Calderon-Montano, J.M.; Burgos Moron, E.; Valerie, N.C.K.; Wiita, E.; Almloef, I.; Koolmeister, T.; Mateus, A.; Cazares-Koerner, C.; Sanjiv, K.; Homan, E.; Loseva, O.; Baranczewski, P.; Darabi, M.; Mehdizadeh, A.; Fayezi, S.; Jemth, A.
    Piperazin-1-ylpyridazine derivatives are a novel class of human dCTP pyrophosphatase 1 inhibitors (2017), J. Med. Chem., 60, 4279-4292 .
    View publication on PubMed
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Application

Application Comment Organism
drug development the enzyme is a drug target Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
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 Homo sapiens
additional information piperazin-1-ylpyridazine derivatives as human dCTP pyrophosphatase 1 inhibitors, overview. Lead compounds increase dCTPase thermal and protease stability, display outstanding selectivity over related enzymes and synergize with a cytidine analogue against leukemic cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H773
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-

Synonyms

Synonyms Comment Organism
dCTP pyrophosphatase 1
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 Homo sapiens
dCTPase
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 Homo sapiens

General Information

General Information Comment Organism
physiological function the dCTPase pyrophosphatase 1 (dCTPase) is an all-alpha nucleoside triphosphate (NTP) pyrophosphatase responsible for dNTP pool house-cleaning. It regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness Homo sapiens