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show all sequences of 3.6.1.12

dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas

Zhang, Y.; Ye, W.Y.; Wang, J.Q.; Wang, S.J.; Ji, P.; Zhou, G.Y.; Zhao, G.P.; Ge, H.L.; Wang, Y.; Eur. J. Histochem. 57, e29 (2013)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme accumulates in the nucleus of cancer cells compared to the paired adjacent tissue cells in multiple carcinomas including lung, breast, liver, cervical, gastric and esophagus cancer. The higher expression in the nucleus of lung, gastric and esophagus cancer cells is associated with histological subtypes. The nucleic accumulation is apparently observed as well when tumor cell line MCF-7 is treated with H2O2 in vitro
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
enzyme accumulates in the nucleus of tumor cells
Homo sapiens
5634
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9H773
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
MCF-7 cell
-
Homo sapiens
-
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme accumulates in the nucleus of cancer cells compared to the paired adjacent tissue cells in multiple carcinomas including lung, breast, liver, cervical, gastric and esophagus cancer. The higher expression in the nucleus of lung, gastric and esophagus cancer cells is associated with histological subtypes. The nucleic accumulation is apparently observed as well when tumor cell line MCF-7 is treated with H2O2 in vitro
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
enzyme accumulates in the nucleus of tumor cells
Homo sapiens
5634
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
MCF-7 cell
-
Homo sapiens
-
Other publictions for EC 3.6.1.12
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734816
Song
Human dCTP pyrophosphatase 1 p ...
Homo sapiens
Oncogenesis
4
e159
2015
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1
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7
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2
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3
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7
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1
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8
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7
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1
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1
1
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7
7
733297
Requena
The NTP pyrophosphatase DCTPP1 ...
Homo sapiens
Biochem. J.
459
171-180
2014
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1
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1
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8
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1
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2
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3
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3
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9
1
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8
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1
1
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8
8
733777
Zhang
dCTP pyrophosphohydrase exhibi ...
Homo sapiens
Eur. J. Histochem.
57
e29
2013
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1
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1
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2
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719287
Corson
Triptolide directly inhibits d ...
Homo sapiens
ChemBioChem
12
1767-1773
2011
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1
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5
1
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1
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Nonaka
Mouse RS21-C6 is a mammalian 2 ...
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276
1654-1666
2009
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1
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14
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13
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Mosig
Several new bacteriophage t4 g ...
Escherichia virus T4
Gene
223
143-155
1998
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Gary
A species barrier between bact ...
Enterobacteria phage T2, Escherichia virus T4
Genetics
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1461-1473
1998
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Neale
Enzymes of pyrimidine deoxyrib ...
Mycoplasma mycoides
J. Bacteriol.
156
1001-1005
1983
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Escherichia virus T4
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Escherichia virus T4
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15087-15097
1982
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209856
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Enterobacteria phage T2
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