Data extracted from this reference:
Cloned(Commentary)
Engineering
E63Q
catalytically inactive
Homo sapiens
KM Value [mM]
0.0092
5-formyl-dCTP
pH 8.0, 25°C
Homo sapiens
0.0168
5-iodo-dCTP
pH 8.0, 25°C
Homo sapiens
0.0333
5-Methyl-dCTP
pH 8.0, 25°C
Homo sapiens
0.0365
5-bromo-dCTP
pH 8.0, 25°C
Homo sapiens
0.0476
dCTP
pH 8.0, 25°C
Homo sapiens
0.0629
5-hydroxymethyl-dCTP
pH 8.0, 25°C
Homo sapiens
0.065
dTTP
pH 8.0, 25°C
Homo sapiens
0.0793
dATP
pH 8.0, 25°C
Homo sapiens
Molecular Weight [Da]
20800
x * 20800, recombinant protein with His-tag, SDS-PAGE
Homo sapiens
Organism
Purification (Commentary)
Source Tissue
Substrates and Products (Substrate)
5-bromo-dCTP + H2O
733297
Homo sapiens
5-bromo-dCMP + diphosphate
?
5-formyl-dCTP + H2O
733297
Homo sapiens
5-formyl-dCMP + diphosphate
?
5-hydroxymethyl-dCTP + H2O
733297
Homo sapiens
5-hydroxymethyl-dCMP + diphosphate
?
5-iodo-dCTP + H2O
733297
Homo sapiens
5-iodo-dCMP + diphosphate
?
5-methyl-dCTP + H2O
733297
Homo sapiens
5-methyl-dCMP + diphosphate
?
dATP + H2O
733297
Homo sapiens
dAMP + diphosphate
?
dCTP + H2O
733297
Homo sapiens
dCMP + diphosphate
?
dTTP + H2O
733297
Homo sapiens
dTMP + diphosphate
?
additional information
no substrtaes: ATP, CTP, UTP, dCDP, 5-methyl-dCDP, dGTP. Poor substrate: dUTP
733297
Homo sapiens
?
?
Subunits
?
x * 20800, recombinant protein with His-tag, SDS-PAGE
Homo sapiens
Synonyms
XTP3-transactivated protein A
Homo sapiens
Turnover Number [1/s]
1.8
dTTP
pH 8.0, 25°C
Homo sapiens
2
dATP
pH 8.0, 25°C
Homo sapiens
3
5-formyl-dCTP
pH 8.0, 25°C
Homo sapiens
4.8
5-Methyl-dCTP
pH 8.0, 25°C
Homo sapiens
5.6
5-hydroxymethyl-dCTP
pH 8.0, 25°C
Homo sapiens
5.7
dCTP
pH 8.0, 25°C
Homo sapiens
6.2
5-iodo-dCTP
pH 8.0, 25°C
Homo sapiens
9.3
5-bromo-dCTP
pH 8.0, 25°C
Homo sapiens
Cloned(Commentary) (protein specific)
Engineering (protein specific)
E63Q
catalytically inactive
Homo sapiens
KM Value [mM] (protein specific)
0.0092
5-formyl-dCTP
pH 8.0, 25°C
Homo sapiens
0.0168
5-iodo-dCTP
pH 8.0, 25°C
Homo sapiens
0.0333
5-Methyl-dCTP
pH 8.0, 25°C
Homo sapiens
0.0365
5-bromo-dCTP
pH 8.0, 25°C
Homo sapiens
0.0476
dCTP
pH 8.0, 25°C
Homo sapiens
0.0629
5-hydroxymethyl-dCTP
pH 8.0, 25°C
Homo sapiens
0.065
dTTP
pH 8.0, 25°C
Homo sapiens
0.0793
dATP
pH 8.0, 25°C
Homo sapiens
Molecular Weight [Da] (protein specific)
20800
x * 20800, recombinant protein with His-tag, SDS-PAGE
Homo sapiens
Purification (Commentary) (protein specific)
Source Tissue (protein specific)
Substrates and Products (Substrate) (protein specific)
5-bromo-dCTP + H2O
733297
Homo sapiens
5-bromo-dCMP + diphosphate
?
5-formyl-dCTP + H2O
733297
Homo sapiens
5-formyl-dCMP + diphosphate
?
5-hydroxymethyl-dCTP + H2O
733297
Homo sapiens
5-hydroxymethyl-dCMP + diphosphate
?
5-iodo-dCTP + H2O
733297
Homo sapiens
5-iodo-dCMP + diphosphate
?
5-methyl-dCTP + H2O
733297
Homo sapiens
5-methyl-dCMP + diphosphate
?
dATP + H2O
733297
Homo sapiens
dAMP + diphosphate
?
dCTP + H2O
733297
Homo sapiens
dCMP + diphosphate
?
dTTP + H2O
733297
Homo sapiens
dTMP + diphosphate
?
additional information
no substrtaes: ATP, CTP, UTP, dCDP, 5-methyl-dCDP, dGTP. Poor substrate: dUTP
733297
Homo sapiens
?
?
Subunits (protein specific)
?
x * 20800, recombinant protein with His-tag, SDS-PAGE
Homo sapiens
Turnover Number [1/s] (protein specific)
1.8
dTTP
pH 8.0, 25°C
Homo sapiens
2
dATP
pH 8.0, 25°C
Homo sapiens
3
5-formyl-dCTP
pH 8.0, 25°C
Homo sapiens
4.8
5-Methyl-dCTP
pH 8.0, 25°C
Homo sapiens
5.6
5-hydroxymethyl-dCTP
pH 8.0, 25°C
Homo sapiens
5.7
dCTP
pH 8.0, 25°C
Homo sapiens
6.2
5-iodo-dCTP
pH 8.0, 25°C
Homo sapiens
9.3
5-bromo-dCTP
pH 8.0, 25°C
Homo sapiens
General Information
physiological function
DCTPP1-deficient cells accumulate high levels of dCTP and are hypersensitive to exposure to the nucleoside analogues 5-iodo-2'-deoxycytidine and 5-methyl-2'-deoxycytidine
Homo sapiens
General Information (protein specific)
physiological function
DCTPP1-deficient cells accumulate high levels of dCTP and are hypersensitive to exposure to the nucleoside analogues 5-iodo-2'-deoxycytidine and 5-methyl-2'-deoxycytidine
Homo sapiens
KCat/KM [mM/s]
25
dATP
pH 8.0, 25°C
Homo sapiens
28
dTTP
pH 8.0, 25°C
Homo sapiens
90
5-hydroxymethyl-dCTP
pH 8.0, 25°C
Homo sapiens
119
dCTP
pH 8.0, 25°C
Homo sapiens
143
5-Methyl-dCTP
pH 8.0, 25°C
Homo sapiens
256
5-bromo-dCTP
pH 8.0, 25°C
Homo sapiens
322
5-formyl-dCTP
pH 8.0, 25°C
Homo sapiens
371
5-iodo-dCTP
pH 8.0, 25°C
Homo sapiens
KCat/KM [mM/s] (protein specific)
25
dATP
pH 8.0, 25°C
Homo sapiens
28
dTTP
pH 8.0, 25°C
Homo sapiens
90
5-hydroxymethyl-dCTP
pH 8.0, 25°C
Homo sapiens
119
dCTP
pH 8.0, 25°C
Homo sapiens
143
5-Methyl-dCTP
pH 8.0, 25°C
Homo sapiens
256
5-bromo-dCTP
pH 8.0, 25°C
Homo sapiens
322
5-formyl-dCTP
pH 8.0, 25°C
Homo sapiens
371
5-iodo-dCTP
pH 8.0, 25°C
Homo sapiens
Other publictions for EC 3.6.1.12
755792
Friese
Chemical genetics reveals a r ...
Homo sapiens
Angew. Chem. Int. Ed. Engl.
58
13009-13013
2019
-
-
1
-
1
-
5
2
-
-
-
2
-
1
-
-
1
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
1
-
4
-
-
1
-
-
1
-
4
5
1
2
-
-
-
2
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
756417
Martinez-Arribas
DCTPP1 prevents a mutator phe ...
Homo sapiens
Cell. Mol. Life Sci.
77
1645-1660
2019
-
1
-
-
1
-
-
-
3
-
-
2
-
3
-
-
-
-
-
1
-
-
2
-
5
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
756185
Llona-Minguez
Diverse heterocyclic scaffold ...
Homo sapiens
Bioorg. Med. Chem. Lett.
27
3219-3225
2017
-
-
-
-
-
-
51
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
17
-
-
-
-
-
-
-
17
53
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
756187
Llona-Minguez
Diverse heterocyclic scaffold ...
Homo sapiens
Bioorg. Med. Chem. Lett.
27
3897-3904
2017
-
-
-
-
-
-
69
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
42
-
-
-
-
-
-
-
42
69
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
757389
Llona-Minguez
Identification of triazolothi ...
Homo sapiens
J. Med. Chem.
60
2148-2154
2017
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
757391
Llona-Minguez
Piperazin-1-ylpyridazine deri ...
Homo sapiens
J. Med. Chem.
60
4279-4292
2017
-
1
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755999
Guiomar
The nucleotidohydrolases DCTP ...
Homo sapiens
Biochem. J.
473
2635-2643
2016
-
1
1
-
1
-
-
1
-
1
-
1
-
2
-
-
-
-
-
1
-
-
2
-
4
2
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
2
6
6
2
-
-
757386
Llona-Minguez
Discovery of the first potent ...
Homo sapiens
J. Med. Chem.
59
1140-1148
2016
-
-
-
-
-
-
37
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
32
-
-
-
-
-
-
-
32
37
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
734816
Song
Human dCTP pyrophosphatase 1 p ...
Homo sapiens
Oncogenesis
4
e159
2015
-
-
-
1
-
-
-
7
-
-
-
-
-
4
-
-
-
-
-
3
-
-
8
-
-
-
-
-
7
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
3
-
-
8
-
-
-
-
7
-
1
-
-
-
1
1
-
7
7
733297
Requena
The NTP pyrophosphatase DCTPP1 ...
Homo sapiens
Biochem. J.
459
171-180
2014
-
-
1
-
1
-
-
8
-
-
1
-
-
6
-
-
1
-
-
3
-
-
9
1
2
-
-
-
8
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
8
-
-
1
-
-
-
-
1
-
3
-
-
9
1
-
-
-
8
-
-
-
-
-
1
1
-
8
8
733777
Zhang
dCTP pyrophosphohydrase exhibi ...
Homo sapiens
Eur. J. Histochem.
57
e29
2013
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
719287
Corson
Triptolide directly inhibits d ...
Homo sapiens
ChemBioChem
12
1767-1773
2011
-
-
1
-
-
-
5
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
2
-
-
-
1
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
5
4
1
-
-
1
-
-
-
-
1
-
-
-
-
2
1
-
-
-
1
-
-
-
-
1
-
-
1
1
1
722230
Nonaka
Mouse RS21-C6 is a mammalian 2 ...
Mus musculus
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2009
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1
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1
13
1
3
2
-
-
3
-
-
-
-
-
3
-
-
14
1
4
1
-
-
13
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
13
1
3
2
-
-
-
-
-
-
3
-
-
14
1
1
-
-
13
1
-
-
-
-
-
-
-
13
13
209857
Mosig
Several new bacteriophage t4 g ...
Escherichia virus T4
Gene
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1998
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1
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-
-
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-
-
-
-
-
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209858
Gary
A species barrier between bact ...
Enterobacteria phage T2, Escherichia virus T4
Genetics
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1461-1473
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9
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-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
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-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
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-
-
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-
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Neale
Enzymes of pyrimidine deoxyrib ...
Mycoplasma mycoides
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5
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-
-
-
-
-
-
2
-
-
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-
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-
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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T4 phage deoxyribonucleotide-s ...
Escherichia virus T4
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-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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Chiu
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
-
-
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-
-
-
-
-
-
-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209856
Zimmerman
Deoxycytidine di- and triphosp ...
Enterobacteria phage T2
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1480-1486
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-
-
-
-
-
-
4
-
-
1
-
-
-
1
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1
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-
1
-
2
-
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-
-
1
1
-
-
-
-
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-
-
-
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-
-
-
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4
-
-
-
1
-
-
-
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-
1
-
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1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-