BRENDA - Enzyme Database show
show all sequences of 3.6.1.12

Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli

Zimmerman, S.B.; Kornberg, A.; J. Biol. Chem. 236, 1480-1486 (1961)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
dCDP
competitive inhibition of hydrolysis of dCTP
Enterobacteria phage T2
dCMP
competitive inhibition of hydrolysis of dCTP and dCDP
Enterobacteria phage T2
dCTP
competitive inhibition of hydrolysis of dCDP
Enterobacteria phage T2
F-
-
Enterobacteria phage T2
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Enterobacteria phage T2
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Enterobacteria phage T2
-
Escherichia coli infected with bacteriophage T2r+, activity found in uninfected cells is 0.1% or less of that found in uninfected cells
-
Purification (Commentary)
Commentary
Organism
-
Enterobacteria phage T2
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
-
Enterobacteria phage T2
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dCDP + H2O
-
209856
Enterobacteria phage T2
?
-
-
-
?
dCTP + H2O
-
209856
Enterobacteria phage T2
dCMP + diphosphate
-
209856
Enterobacteria phage T2
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
-
Enterobacteria phage T2
pH Range
pH Minimum
pH Maximum
Commentary
Organism
8
10
pH 8.0: about 55% of maximal activity, pH 10.0: about 35% of maximal activity
Enterobacteria phage T2
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
dCDP
competitive inhibition of hydrolysis of dCTP
Enterobacteria phage T2
dCMP
competitive inhibition of hydrolysis of dCTP and dCDP
Enterobacteria phage T2
dCTP
competitive inhibition of hydrolysis of dCDP
Enterobacteria phage T2
F-
-
Enterobacteria phage T2
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Enterobacteria phage T2
Purification (Commentary) (protein specific)
Commentary
Organism
-
Enterobacteria phage T2
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
-
Enterobacteria phage T2
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dCDP + H2O
-
209856
Enterobacteria phage T2
?
-
-
-
?
dCTP + H2O
-
209856
Enterobacteria phage T2
dCMP + diphosphate
-
209856
Enterobacteria phage T2
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
-
Enterobacteria phage T2
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
8
10
pH 8.0: about 55% of maximal activity, pH 10.0: about 35% of maximal activity
Enterobacteria phage T2
Other publictions for EC 3.6.1.12
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734816
Song
Human dCTP pyrophosphatase 1 p ...
Homo sapiens
Oncogenesis
4
e159
2015
-
-
-
1
-
-
-
7
-
-
-
-
-
2
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3
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8
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7
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1
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1
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7
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3
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8
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7
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1
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1
1
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7
7
733297
Requena
The NTP pyrophosphatase DCTPP1 ...
Homo sapiens
Biochem. J.
459
171-180
2014
-
-
1
-
1
-
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8
-
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1
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2
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1
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3
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9
1
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8
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1
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1
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8
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1
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1
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3
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9
1
-
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8
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-
-
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-
1
1
-
8
8
733777
Zhang
dCTP pyrophosphohydrase exhibi ...
Homo sapiens
Eur. J. Histochem.
57
e29
2013
-
1
-
-
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-
-
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1
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2
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1
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1
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1
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1
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-
719287
Corson
Triptolide directly inhibits d ...
Homo sapiens
ChemBioChem
12
1767-1773
2011
-
-
1
-
-
-
5
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
-
1
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4
-
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1
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5
4
1
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1
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1
-
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-
-
2
1
-
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1
-
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1
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1
1
1
722230
Nonaka
Mouse RS21-C6 is a mammalian 2 ...
Mus musculus
FEBS J.
276
1654-1666
2009
-
-
1
-
-
-
1
13
1
3
2
-
-
2
-
-
-
-
-
3
-
-
14
1
1
-
-
13
1
-
-
-
-
-
-
-
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1
-
-
-
-
-
1
-
13
1
3
2
-
-
-
-
-
-
3
-
-
14
1
1
-
-
13
1
-
-
-
-
-
-
-
13
13
209857
Mosig
Several new bacteriophage t4 g ...
Escherichia virus T4
Gene
223
143-155
1998
-
-
1
-
-
-
-
-
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1
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1
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1
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1
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-
209858
Gary
A species barrier between bact ...
Enterobacteria phage T2, Escherichia virus T4
Genetics
148
1461-1473
1998
-
-
2
-
-
-
-
-
-
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2
-
4
-
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4
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2
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2
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4
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-
209853
Neale
Enzymes of pyrimidine deoxyrib ...
Mycoplasma mycoides
J. Bacteriol.
156
1001-1005
1983
-
-
-
-
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1
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3
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2
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1
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2
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209854
Allen
T4 phage deoxyribonucleotide-s ...
Escherichia virus T4
J. Biol. Chem.
258
5746-5753
1983
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-
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1
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1
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1
1
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1
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1
1
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-
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-
209855
Chiu
Characteristics of a bacteriop ...
Escherichia virus T4
J. Biol. Chem.
257
15087-15097
1982
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1
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1
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1
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209856
Zimmerman
Deoxycytidine di- and triphosp ...
Enterobacteria phage T2
J. Biol. Chem.
236
1480-1486
1961
-
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4
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1
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1
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1
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1
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2
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1
1
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4
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1
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1
1
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