Literature summary for 3.6.1.11 extracted from

Gallarato, L.A.; Sanchez, D.G.; Olvera, L.; Primo, E.D.; Garrido, M.N.; Beassoni, P.R.; Morett, E.; Lisa, A.T.
Exopolyphosphatase of Pseudomonas aeruginosa is essential for the production of virulence factors, and its expression is controlled by NtrC and PhoB acting at two interspaced promoters (2014), Microbiology, 160, 406-417.

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	Q9ZN70	-	-

Synonyms

Synonyms	Comment	Organism
PPX	-	Pseudomonas aeruginosa

Expression

Organism	Comment	Expression
Pseudomonas aeruginosa	under nitrogen-limiting conditions, exopolyphosphatase expression is controlled from a sigma54-dependent promoter activated by the response regulator NtrC. Under phosphate limitation, the expression is controlled from a sigma70 promoter, activated by PhoB	additional information

General Information

General Information	Comment	Organism
physiological function	exopolyphosphatase Ppx is involved in the production of virulence factors associated with both acute infection (e.g. motility-promoting factors, blue/green pigment production, C6-C12 quorum-sensing homoserine lactones) and chronic infection (e.g. rhamnolipids, biofilm formation). Pseudomonas aeruginosa maintains consistently proper levels of Ppx regardless of environmental conditions. A mutant strain lacking Ppx activity does not grow in phosphate-deficient medium and the survival after 8 or 24 h declines by 25-30% of the initial value	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)