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Literature summary for 3.6.1.11 extracted from

  • Thayil, S.M.; Morrison, N.; Schechter, N.; Rubin, H.; Karakousis, P.C.
    The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence (2011), PLoS ONE, 6, e28076.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Arctic Express (DE3) cells Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36600
-
 x * 36600, SDS-PAGE Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WHV4
-
-
Mycobacterium tuberculosis CDC 1551 P9WHV4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(phosphate)n + H2O
-
 Mycobacterium tuberculosis (phosphate)n-1 + phosphate
-
 ?
(phosphate)n + H2O
-
 Mycobacterium tuberculosis CDC 1551 (phosphate)n-1 + phosphate
-
 ?
additional information the enzyme does not cleave ppGpp Mycobacterium tuberculosis ?
-
 ?
additional information the enzyme does not cleave ppGpp Mycobacterium tuberculosis CDC 1551 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 36600, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
MT0516
-
 Mycobacterium tuberculosis
PPX
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction deficiency of exopolyphosphatase results in decelerated growth during logarithmic-phase in axenic cultures, and tolerance to the cell wall-active drug isoniazid. The enzyme-deficient mutant shows a significant survival defect in activated human macrophages and reduced persistence in the lungs of guinea pigs Mycobacterium tuberculosis
physiological function exopolyphosphatase is required for long-term survival of Mycobacterium tuberculosis in necrotic lung lesion Mycobacterium tuberculosis