Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.11 extracted from

  • Zhang, Q.; Li, Y.; Tang, C.M.
    The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing (2010), J. Biol. Chem., 285, 34259-34268.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.11

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ in the presence of Ca2+, the activity is about 20% of levels with Mg2+ Neisseria meningitidis
Mg2+ the activity of NMB1467 is dependent on Mg2+ with optimal activity observed with between 1 and 2 mM Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(polyphosphate)n + H2O Neisseria meningitidis
-
 (polyphosphate)n-1 + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(polyphosphate)n + H2O
-
 Neisseria meningitidis (polyphosphate)n-1 + phosphate
-
 ?
polyphosphate 75 + H2O
-
 Neisseria meningitidis polyphosphate 74 + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
exopolyphosphatase
-
 Neisseria meningitidis
NMB1467
-
 Neisseria meningitidis
PPX
-
 Neisseria meningitidis

General Information

General Information Comment Organism
malfunction bacteria lacking PPX exhibit increased resistance to complement-mediated killing. Loss of PPX leads to decrease in alternative pathway activation on bacterial surface Neisseria meningitidis
physiological function the biochemical activity of PPX is necessary for interactions with the complement Neisseria meningitidis