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Literature summary for 3.6.1.1 extracted from
- Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism (2006), Biochem. Biophys. Res. Commun., 341, 691-696.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of His-tagged enzyme in Escherichia coli strain BL21(DE3) | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + H2O | Homo sapiens | LHPPase is associated with hyperthyroidism | 2 phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| follicular adenoma cell | - |
Homo sapiens | - |
| additional information | no expression of the enzyme in fibroblasts, endothelial cells, and adipocytes within the stroma in thyroid tissues, overview | Homo sapiens | - |
| papillary thyroid cancer cell | - |
Homo sapiens | - |
| thyrocyte | nuclear expression is lost in cultured cells, while the cytosolic expression is retained | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + H2O | - |
Homo sapiens | 2 phosphate | - |
? | |
| diphosphate + H2O | LHPPase is associated with hyperthyroidism | Homo sapiens | 2 phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| inorganic pyrophosphatase | - |
Homo sapiens |
| LHPPase | - |
Homo sapiens |
| phospholysine phosphohistidine inorganic pyrophosphate phosphatase | - |
Homo sapiens |
| PPase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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