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Literature summary for 3.6.1.1 extracted from

  • Rantanen, M.K.; Lehtioe, L.; Rajagopal, L.; Rubens, C.E.; Goldman, A.
    Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution (2007), Acta Crystallogr. Sect. D, 63, 738-743.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.1

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed enzyme with each enzyme monomer containing the diphosphate analogue imidodiphosphate and three metal ions per active site: two Mn2+ ions in sites M1 and M2 and an Mg2+ ion in site M3, X-ray diffraction structure determination and analysis at 2.8 A resolution, molecular replacement Streptococcus agalactiae

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Streptococcus agalactiae
Mg2+ binding structure, overview Streptococcus agalactiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diphosphate + H2O Streptococcus agalactiae
-
 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae Q8DYS6
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is probably phosphorylated at Ser150 and Ser296 near the active site, and at Ser194 and Ser195 near the hinge region Streptococcus agalactiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diphosphate + H2O
-
 Streptococcus agalactiae 2 phosphate
-
 ?
additional information active site residues are His9, Arg13, Asp15, Asp77, His99, His100, Asp151, Lys207, Arg297 and Lys298 Streptococcus agalactiae ?
-
 ?

Subunits

Subunits Comment Organism
dimer the enzyme structure consists of two domains, comprising residues 1-191 and 198-311, respectively, with the active site located between them, overview Streptococcus agalactiae

Synonyms

Synonyms Comment Organism
family II inorganic pyrophosphatase
-
 Streptococcus agalactiae