Literature summary for 3.6.1.1 extracted from

Stefanovic, V.; Mandel, P.; Rosenberg, A.
Properties of ecto-(inoganic) pyrophosphatase of nervous system cells in culture. Activation upon partial release of sialic acid from the cell surface (1976), J. Biol. Chem., 251, 493-497.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	-	Cricetinae
Cd2+	-	Cricetinae
Cu2+	-	Cricetinae
Hg2+	-	Cricetinae
Mn2+	-	Cricetinae
Zn2+	-	Cricetinae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.06	-	diphosphate	Mg2+ at 5 mM, enzyme from astroblasts	Cricetinae
0.07	-	diphosphate	Mg2+ at 5 mM, enzyme from neuroblasts	Cricetinae
2.27	-	Mg2+	diphosphate at 1 mM, enzyme from astroblasts	Cricetinae
3.15	-	Mg2+	diphosphate at 1 mM, enzyme from neuroblasts	Cricetinae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	ectoenzyme	Cricetinae	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required for activity	Cricetinae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
diphosphate + H2O	Cricetinae	actual substrate is magnesium diphosphate or dimagnesium diphosphate	2 phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Cricetinae	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astroblast	clonal line NN, cell culture	Cricetinae	-
neuroblast	clonal line N18, cell culture	Cricetinae	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
diphosphate + H2O	actual substrate is magnesium diphosphate or dimagnesium diphosphate	Cricetinae	2 phosphate	-	?

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Release 2023.1 (January 2023)