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Literature summary for 3.5.5.8 extracted from
- Thiocyanate hydrolase is a cobalt-containing metalloenzyme with a cysteine-sulfinic acid ligand (2006), J. Am. Chem. Soc., 128, 728-729.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| DNA and amino acid sequence determination and analysis | Thiobacillus thioparus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | cobalt-containing metalloenzyme, 1 Co2+ per enzyme trimer, binding site, H124VVVCTLCSCYPRPILGQSPEWYR147, in the gamma-subunit with close relation to nitrile hydratase, absorption spectrum analysis, overview | Thiobacillus thioparus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiocyanate + H2O | Thiobacillus thioparus | - |
carbonyl sulfide + NH3 + OH- | - |
? | |
| thiocyanate + H2O | Thiobacillus thioparus THI115 | - |
carbonyl sulfide + NH3 + OH- | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thiobacillus thioparus | - |
- |
- |
| Thiobacillus thioparus THI115 | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | Cys113 is posttranslationally oxidized to cysteinesulfinic acid | Thiobacillus thioparus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | the organism is obligately chemilithoautotrophic sulfur-oxidizing and uses thiocyanate as sole energy source | Thiobacillus thioparus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiocyanate + H2O | - |
Thiobacillus thioparus | carbonyl sulfide + NH3 + OH- | - |
? | |
| thiocyanate + H2O | via multiple reaction steps | Thiobacillus thioparus | carbonyl sulfide + NH3 + OH- | - |
? | |
| thiocyanate + H2O | - |
Thiobacillus thioparus THI115 | carbonyl sulfide + NH3 + OH- | - |
? | |
| thiocyanate + H2O | via multiple reaction steps | Thiobacillus thioparus THI115 | carbonyl sulfide + NH3 + OH- | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | heterotrimer alphabetagamma | Thiobacillus thioparus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SCNase | - |
Thiobacillus thioparus |
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Release 2023.1 (January 2023)
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