Literature summary for 3.5.5.1 extracted from

Zhang, H.; Hou, Y.J.; Han, S.Y.; Zhang, E.C.; Huebner, K.; Zhang, J.
Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells (2009), Int. Immunol., 21, 691-703.

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Protein Variants

Protein Variants	Comment	Organism
additional information	Nit1-deficient T-lymphocytes of knock-out mice can undergo apoptosis induced by DNA damage due to irradiation and chemical treatment. Apoptosis induced by Fas or Ca2+ signals appears to be compromised. Nit1 deficiency results in T-lymphocyte hyperproliferative responses induced by T-lymphocyte receptor stimulation. The expressions of T-lymphocyte activation markers are elevated in Nit1-/- T-lymphocytes. There is a spontaneous cell cycle entry and enhanced cell cycle progression in Nit1-/- T-lymphocytes	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform Nit1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-lymphocyte	-	Mus musculus	-

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Release 2023.1 (January 2023)