Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.B9 extracted from

  • Senavirathne, G.; Jaszczur, M.; Auerbach, P.A.; Upton, T.G.; Chelico, L.; Goodman, M.F.; Rueda, D.
    Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution (2012), J. Biol. Chem., 287, 15826-15835.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.B9

Activating Compound

Activating Compound Comment Organism Structure
additional information large increase in the mobility of APOBEC3G cytidine deaminase on ssDNA at higher salt, Mg2+ or NaCl Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ large increase in the mobility of APOBEC3G cytidine deaminase on ssDNA at higher salt, Mg2+ or NaCl Homo sapiens
NaCl large increase in the mobility of APOBEC3G cytidine deaminase on ssDNA at higher salt, Mg2+ or NaCl Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded viral DNA + H2O Homo sapiens phage M13mp2 circular DNA containing a series of in-frame 5'-AAACCCAAA hot motifs embedded in lacZalpha reporter sequence located within a single-stranded gapped region of M13 double-stranded DNA. The third C in the 5'-AAACCCAAA motif is deaminated predominantly uracil in single-stranded viral DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded viral DNA + H2O phage M13mp2 circular DNA containing a series of in-frame 5'-AAACCCAAA hot motifs embedded in lacZalpha reporter sequence located within a single-stranded gapped region of M13 double-stranded DNA. The third C in the 5'-AAACCCAAA motif is deaminated predominantly Homo sapiens uracil in single-stranded viral DNA + NH3
-
 ?
additional information APOBEC3G cytidine deaminase contracts ssDNA in a deamination motif-dependent manner, presence of bidirectional quasi-localized scanning of APOBEC3G cytidine deaminase occurring proximal to a 5' hot motif, a motif-dependent DNA contraction greatest for 5' hot before 3' hot before 5' cold motifs, and diminished mobility at low salt, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More APOBEC3G cytidine deaminase catalytically inactive N-terminal CD1 domain has a predicted large net positive charge, in contrast to the catalytically active CD2 domain, and is likely to govern the mobility of APOBEC3G cytidine deaminase on ssDNA, which should depend on metal ion concentration Homo sapiens

Synonyms

Synonyms Comment Organism
Apo3G
-
 Homo sapiens
APOBEC3G
-
 Homo sapiens
APOBEC3G cytidine deaminase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the single-stranded DNA-dependent cytosine deaminase inactivates HIV-1 in T cells by C to T hypermutation Homo sapiens