Any feedback?
Literature summary for 3.5.4.9 extracted from
- 5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate (2003), Biochem. J., 374, 773-778.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Rattus norvegicus | |
| 0.009 | - |
10-formyltetrahydrofolate | pH 7.0, 23°C | Rattus norvegicus |  |
| 0.009 | - |
5,10-methenyltetrahydrofolate | pH 7.0, 23°C | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the determined amount of 5-formyltetrahydrofolate formation in the liver is low, possible role in one-carbon metabolism | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0002 | - |
cyclohydrolase activity, rat liver, formation of 5-formyltetrahydrofolate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate | low activity in the liver | Rattus norvegicus | 5,10-methenyltetrahydrofolate + H2O | - |
? | |
| 5,10-methenyltetrahydrofolate + H2O | - |
Rattus norvegicus | 10-formyltetrahydrofolate | - |
r | |
| 5,10-methenyltetrahydrofolate + H2O | - |
Rattus norvegicus | 5-formyltetrahydrofolate | - |
r | |
| additional information | the determined amount of 5-formyltetrahydrofolate formation in the liver is low, possible role in one-carbon metabolism | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5,10-CH=H4 folate synthetase | - |
Rattus norvegicus |
| 5,10-methenyltetrahydrofolate cyclohydrolase | - |
Rattus norvegicus |
| 5,10-Methenyltetrahydrofolate synthetase | - |
Rattus norvegicus |
| More | 5,10-methenyltetrahydrofolate cyclohydrolase and 5,10-methenyltetrahydrofolate synthetase might be 2 different enzymes | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 7 | 5-formyltetrahydrofolate formation | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
