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Literature summary for 3.5.4.9 extracted from

  • Tabor, H.; Wyngarden, L.
    The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid (1959), J. Biol. Chem., 234, 1830-1846.
    View publication on PubMed
Search for more literature for 3.5.4.9

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 5,10-methenyltetrahydrofolate
-
 Oryctolagus cuniculus
0.074
-
 5,10-methenyltetrahydrofolate
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O Cavia porcellus
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Mus musculus
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Homo sapiens
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Rattus norvegicus
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Sus scrofa
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Bos taurus
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Oryctolagus cuniculus
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Ovis aries
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Pseudomonas fluorescens
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Clostridium cylindrosporum
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Gottschalkia acidurici
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Felis sp.
-
 10-formyltetrahydrofolate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 beef
-
Cavia porcellus
-
 guinea-pig
-
Clostridium cylindrosporum
-
-
-
Felis sp.
-
 cat
-
Gottschalkia acidurici
-
-
-
Homo sapiens
-
 human, bifunctional mitochondrial enzyme, trifunctional cytoplasmic enzyme
-
Mus musculus
-
 mouse, bifunctional mitochondrial enzyme
-
Oryctolagus cuniculus
-
 rabbit
-
Ovis aries
-
-
-
Pseudomonas fluorescens
-
 ATCC 11299
-
Rattus norvegicus
-
 rat, trifunctional cytoplasmic enzyme
-
Sus scrofa
-
 pig, trifunctional enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Cavia porcellus
-
kidney
-
 Mus musculus
-
kidney
-
 Rattus norvegicus
-
kidney
-
 Sus scrofa
-
kidney
-
 Bos taurus
-
kidney
-
 Oryctolagus cuniculus
-
kidney
-
 Ovis aries
-
kidney
-
 Felis sp.
-
liver
-
 Cavia porcellus
-
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-
liver
-
 Bos taurus
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Ovis aries
-
liver
-
 Felis sp.
-
spleen
-
 Cavia porcellus
-
spleen
-
 Mus musculus
-
spleen
-
 Rattus norvegicus
-
spleen
-
 Oryctolagus cuniculus
-
spleen
-
 Felis sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.09
-
 source spleen Oryctolagus cuniculus
0.1
-
 source spleen Cavia porcellus
0.1
-
 source kidney Ovis aries
0.13
-
 source kidney Bos taurus
0.14
-
-
 Homo sapiens
0.14
-
-
 Ovis aries
0.16
-
 source spleen Mus musculus
0.18
-
 source liver Rattus norvegicus
0.22
-
 source liver Sus scrofa
0.23
-
-
 Rattus norvegicus
0.23
-
 source spleen Felis sp.
0.25
-
 source kidney Oryctolagus cuniculus
0.27
-
 source liver Felis sp.
0.29
-
-
 Pseudomonas fluorescens
0.35
-
 source kidney Cavia porcellus
0.36
-
 source kidney Rattus norvegicus
0.4
-
 source liver Mus musculus
0.41
-
 source kidney Felis sp.
0.5
-
 source kidney Mus musculus
0.65
-
-
 Bos taurus
0.82
-
 source liver Oryctolagus cuniculus
1.04
-
 source liver Cavia porcellus
2.2
-
-
 Sus scrofa

Storage Stability

Storage Stability Organism
-20°C, loses 15% activity in 1 day, 50% in 5 days and 70% in 30 days Sus scrofa
0°C, relatively unstable, losing 40% activity in 1 day and 75% in 4 days Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O
-
 Cavia porcellus 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Mus musculus 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Homo sapiens 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Rattus norvegicus 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Sus scrofa 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Bos taurus 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Oryctolagus cuniculus 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Ovis aries 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Pseudomonas fluorescens 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Clostridium cylindrosporum 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Gottschalkia acidurici 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Felis sp. 10-formyltetrahydrofolate
-
 ?