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Literature summary for 3.5.4.9 extracted from

  • Tan, L.U.L.; Drury, E.J.; MacKenzie, R.E.
    Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase. A multifunctional protein from porcine liver (1977), J. Biol. Chem., 252, 1117-1122.
    View publication on PubMed

General Stability

General Stability Organism
purified enzyme stored in 20% glycerol, 0.1 M potassium phosphate pH 7.3 stable for about 1 week Sus scrofa
quite unstable, loses all activity after 96 h of storage Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.13
-
5,10-methenyltetrahydrofolate
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
-
Sus scrofa
150000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O Sus scrofa
-
10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O Bos taurus
-
10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O Clostridium cylindrosporum
-
10-formyltetrahydrofolate
-
?

Organic Solvent Stability

Organic Solvent Comment Organism
Glycerol
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Bos taurus
-
beef
-
Clostridium cylindrosporum
-
monofunctional enzyme
-
Sus scrofa
-
pig, trifunctional enzyme
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methenyltetrahydrofolate + H2O
-
Sus scrofa 10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O
-
Bos taurus 10-formyltetrahydrofolate
-
?
5,10-methenyltetrahydrofolate + H2O
-
Clostridium cylindrosporum 10-formyltetrahydrofolate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 100000, SDS-PAGE, single polypeptide chain Sus scrofa