Literature summary for 3.5.4.5 extracted from

Furusho, K.; Shibata, T.; Sato, R.; Fukui, R.; Motoi, Y.; Zhang, Y.; Saitoh, S.I.; Ichinohe, T.; Moriyama, M.; Nakamura, S.; Miyake, K.
Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs (2019), Int. Immunol., 31, 167-173 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P32320	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
leukocyte	high expression level	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CDA	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	CDA enables toll-like receptor TLR8 activation by cytidine or its analogues with ssRNA through deaminating activity. CDA expression enables TLR8 response to cytidine and ssRNA in 293T cells. CDA deficiency and a CDA inhibitor both reduces TLR8 responses to cytidine and ssRNA in U937. The CDA inhibitor also reduces peripheral blood leukocyte response to cytidine and ssRNA. Analogue azacytidine with ssRNA induces tumor necrosis factor-alpha expression in U937 and peripheral blood leukocytes in a manner dependent on CDA and TLR8	Homo sapiens

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Release 2023.1 (January 2023)