Organism | UniProt | Comment | Textmining |
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General Information | Comment | Organism |
---|---|---|
malfunction | impaired central B-cell tolerance and increased serum autoAb in Aicda-/- mice compared to the wild-type | Mus musculus |
physiological function | activation-induced cytidine deaminase initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair. Aicda impairs B-cell development | Mus musculus |