Literature summary for 3.5.4.4 extracted from

Senger, M.R.; Rosemberg, D.B.; Seibt, K.J.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
Influence of mercury chloride on adenosine deaminase activity and gene expression in zebrafish (Danio rerio) brain (2010), Neurotoxicology, 31, 291-296.

Search for more literature for 3.5.4.4

Inhibitors

Inhibitors	Comment	Organism	Structure
HgCl2	inhibition of ADA activity is observed in the soluble fraction at 0.005-0.25 mM HgCl2 (84.6-92.6% respectively), whereas inhibition occurs at 0.005-0.25 mM in membrane fractions (20.9-26% respectively). The inhibition is partially or fully abolished by 0.5 mM dithiothreitol or EDTA	Danio rerio

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Danio rerio	16020	-
soluble	-	Danio rerio	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	there are no significant changes in ADA activity in the presence of cadmium acetate, potassium dichromate, lead acetate, zinc chloride, copper sulfate, cobalt chloride, and manganese chloride	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Danio rerio	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine + H2O	-	Danio rerio	inosine + NH3	-	?

Synonyms

Synonyms	Comment	Organism
ADA	-	Danio rerio

Expression

Organism	Comment	Expression
Danio rerio	HgCl2 does not alter ADA gene expression	additional information

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Release 2023.1 (January 2023)