Organism | UniProt | Comment | Textmining |
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General Information | Comment | Organism |
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malfunction | apoptosis is enhanced in ADAR1-deficient cells following infection with wild type and V knockout measles virus but not following infection with C knockout measles virus or treatment with tumor necrosis factor-alpha or staurosporine | Homo sapiens |
physiological function | ADAR1 is a proviral, antiapoptotic host factor in the context of measles virus infection. ADAR1 enhances the growth of measles virus. ADAR1 suppresses wild type and V knockout measles virus-induced apoptosis. ADAR1 does not protect against tumor necrosis factor-alpha- or staurosporine-induced apoptosis. ADAR1 suppresses wild type and V knockout measles virus-induced protein kinase regulated by RNA activation. ADAR1 suppresses interferon regulatory transcription factor-3 activation by wild type and V knockout measles viruses | Homo sapiens |