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Literature summary for 3.5.4.4 extracted from

  • Poursharifi, P.; Saghiri, R.; Ebrahimi-Rad, M.; Nazem, H.; Pourpak, Z.; Moin, M.; Shams, S.
    Adenosine deaminase in patients with primary immunodeficiency syndromes: The analysis of serum ADA1 and ADA2 activities (2008), Clin. Biochem., 42, 1438-1443.
    View publication on PubMed

Application

Application Comment Organism
diagnostics serum tADA and ADA2 may serve as useful indicators for diagnosis of CGD, LADs, IgA deficiency, SCID, HIM and WAS patients as a supplementary laboratory test in combination with clinical, immunological, and other laboratory findings Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with various primary immunodeficiency (PID) syndromes
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Source Tissue

Source Tissue Comment Organism Textmining
blood serum
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Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
tADA and ADA2 levels are higher in patients with Chronic Granulomatous Disease (CGD), Leukocyte Adhesion Deficiency (LAD), hyper IgM (HIM) and Wiskott-Aldrich Syndrome (WAS) than those of corresponding controls. There is a significant elevation of tADA and ADA1 activities in IgA deficiency patients as compared to healthy individuals Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
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Homo sapiens inosine + NH3
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?

Synonyms

Synonyms Comment Organism
ADA
-
Homo sapiens
adenosine deaminase
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Homo sapiens
TadA
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Homo sapiens