Literature summary for 3.5.4.4 extracted from

Belle, L.P.; De Bona, K.S.; Abdalla, F.H.; Pimentel, V.C.; Pigatto, A.S.; Moretto, M.B.
Comparative evaluation of adenosine deaminase activity in cerebral cortex and hippocampus of young and adult rats: effect of garlic extract (Allium sativum L.) on their susceptibility to heavy metal exposure (2009), Basic Clin. Pharmacol. Toxicol., 104, 408-413.

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Inhibitors

Inhibitors	Comment	Organism	Structure
methylmercury	concentration 0.1, 1.0, 20 M, inhibits adenosine deaminase activity in 7- and 60-day-old rats in a concentration-dependent manner, glutathione (50 microM) and dithiothreitol (50 microM) prevent the reduction of adenosine deaminase activity both in cerebral cortex and hippocampus, garlic alcoholic extract (100 microg/ml) abolishes the reduction of adenosine deaminase	Rattus norvegicus
Sodium selenate	does not alter enzyme activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats 7-(P7) and 60-day-old (P60)	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebral cortex	-	Rattus norvegicus	-
hippocampus	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	adenosine deaminase activity is higher in young rat brains when compared to the 60-day-old rats and is higher in hippocampus when compared to the cerebral cortex	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine + H2O	-	Rattus norvegicus	inosine + NH3	-	?

Synonyms

Synonyms	Comment	Organism
adenosine deaminase	-	Rattus norvegicus

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Release 2023.1 (January 2023)