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Literature summary for 3.5.4.4 extracted from
- Kinetic, thermodynamic and statistical studies on the inhibition of adenosine deaminase by aspirin and diclofenac (2007), J. Enzyme Inhib. Med. Chem., 22, 395-406.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetylsalicylic acid | - |
Bos taurus |  |
| diclofenac | competitive at 27°C, uncompetitive at 37°C | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Bos taurus | - |
| intestine | mucosa, commercial preparation | Bos taurus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADA | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 27 | 37 | assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics and thermodynamic effects of inhibitors, QSAR analysis, overview | Bos taurus | |
| 0.03 | - |
diclofenac | pH 7.5, 37°C | Bos taurus | |
| 0.0428 | - |
Acetylsalicylic acid | pH 7.5, 27°C | Bos taurus | |
| 0.0564 | - |
diclofenac | pH 7.5, 27°C | Bos taurus | |
| 0.0968 | - |
Acetylsalicylic acid | pH 7.5, 37°C | Bos taurus | |
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Release 2023.1 (January 2023)
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