Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | Homo sapiens | conformational equilibrium of the APOBEC3B active site loops, skewed toward being closed, controls enzymatic activity by regulating binding to ssDNA substrates | uracil in single-stranded DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UH17 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | - |
Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
cytosine in single-stranded DNA + H2O | conformational equilibrium of the APOBEC3B active site loops, skewed toward being closed, controls enzymatic activity by regulating binding to ssDNA substrates | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APOBEC3B | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme has important roles in innate immunity but is also a major endogenous source of mutations in cancer | Homo sapiens |