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Literature summary for 3.5.4.38 extracted from

  • Feng, Y.; Wong, L.; Morse, M.; Rouzina, I.; Williams, M.C.; Chelico, L.
    RNA-mediated dimerization of the human deoxycytidine deaminase APOBEC3H influences enzyme activity and interaction with nucleic acids (2018), J. Mol. Biol., 430, 4891-4907 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Activating Compound

Activating Compound Comment Organism Structure
RNA RNA binding is integral to APOBEC3H function. RNA-mediated dimerization alters the interactions of the enzyme with ssDNA and other RNA molecules Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens
-
 uracil in single-stranded DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6NTF7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
 Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O RNA binding is integral to APOBEC3H function. RNA-mediated dimerization alters the interactions of the enzyme with ssDNA and other RNA molecules Homo sapiens uracil in single-stranded DNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
APOBEC3H
-
 Homo sapiens
single-stranded (ss)DNA deoxycytidine deaminase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction when aberrantly expressed in lung or breast tissue, APOBEC3H can contribute to cancer mutagenesis Homo sapiens
physiological function the enzyme inhibits replication of retroelements and HIV-1 in CD4+ T cells Homo sapiens