Literature summary for 3.5.4.38 extracted from

Pham, P.; Afif, S.A.; Shimoda, M.; Maeda, K.; Sakaguchi, N.; Pedersen, L.C.; Goodman, M.F.
Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification (2016), DNA Repair, 43, 48-56 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion technique at 4°C, crystal structure of enzyme variant AIDv(DELTA15), at 2.8 A resolution	Escherichia coli O157:H7

Protein Variants

Protein Variants	Comment	Organism
K52A	2fold reduction in processivity	Escherichia coli O157:H7
Q175A	2fold reduction in processivity	Escherichia coli O157:H7
R171A	2fold reduction in processivity	Escherichia coli O157:H7
R178A	2fold reduction in processivity	Escherichia coli O157:H7

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli O157:H7	P0AEY0	-	-

Purification (Commentary)

Purification (Comment)	Organism
Sf9 expressed GST-tagged enzyme	Escherichia coli O157:H7

Synonyms

Synonyms	Comment	Organism
AID	-	Escherichia coli O157:H7

General Information

General Information	Comment	Organism
physiological function	the enzyme initiates somatic hypermutation and class-switch recombination by deaminating C -> U during transcription of Ig-variable and Ig-switch region DNA, which is essential to produce high-affinity antibodies	Escherichia coli O157:H7

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Release 2023.1 (January 2023)