Protein Variants | Comment | Organism |
---|---|---|
S38A | the mutant enzyme shows dimished somatic hypermutation activity on artificial and physiological DNA targets | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | Mus musculus | activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations | uracil in single-stranded DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9WVE0 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | 515% of the enzyme expressed in activated B cells is phosphorylated at Ser38. The modified form contributes disproportionately to hypermutation. This form of activation-induced cytidine deaminase is enriched in the chromatin fraction in activated B cells | Mus musculus |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | - |
Mus musculus | uracil in single-stranded DNA + NH3 | - |
? | |
cytosine in single-stranded DNA + H2O | activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations | Mus musculus | uracil in single-stranded DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activation-induced deaminase | - |
Mus musculus |
AID | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations | Mus musculus |