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Literature summary for 3.5.4.38 extracted from
- Molecular characterization of Pleurodeles waltl activation-induced cytidine deaminase (2010), Mol. Immunol., 47, 1640-1649.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Pleurodeles waltl |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activation-induced cytidine deaminase mRNA is not alternatively spliced in Pleurodeles waltl | Pleurodeles waltl |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Pleurodeles waltl | activation-induced cytidine deaminase is function in Pleurodeles waltl. The lack of class switch recombination activity in Pleurodeles waltl is therefore not due to a defect in expression or function of activation-induced cytidine deaminase | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pleurodeles waltl | D5GRW1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spleen | predominantly expressed in the spleen. The enzyme is expressed early during embryonic development of Pleurodeles waltl | Pleurodeles waltl | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | activation-induced cytidine deaminase is function in Pleurodeles waltl. The lack of class switch recombination activity in Pleurodeles waltl is therefore not due to a defect in expression or function of activation-induced cytidine deaminase | Pleurodeles waltl | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activation-induced cytidine deaminase | - |
Pleurodeles waltl |
| AID | - |
Pleurodeles waltl |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in immunoglobulin affinity maturation, gene conversion and class switch recombination. This protein is therefore a major actor in the creation of the antibody repertoire | Pleurodeles waltl |
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Release 2023.1 (January 2023)
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