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Literature summary for 3.5.4.38 extracted from
- Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID (2007), Mol. Cell. Biol., 27, 8038-8048.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded DNA + H2O | Homo sapiens | the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences | uracil in single-stranded DNA + NH3 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9GZX7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded DNA + H2O | the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
| cytosine in single-stranded DNA + H2O | exclusively catalyses deamination of cytidine in single-stranded DNA. It shows minimal activity on stem-loop structures and preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G). WRC preference involves the recognition of a purine in the R position and that the carbonyl or amino side chains of guanosine negatively influence specificity at the W position | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activation-induced deaminase | - |
Homo sapiens |
| AID | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences | Homo sapiens |
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Release 2023.1 (January 2023)
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