Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine in double-stranded RNA + H2O | Rattus norvegicus | - |
hypoxanthine in double-stranded RNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine in double-stranded RNA + H2O | - |
Rattus norvegicus | hypoxanthine in double-stranded RNA + NH3 | - |
? | |
adenine in double-stranded RNA + H2O | pre-mRNA of glutamate receptor subunit B. ADAR2 selectively edits the R/G site (R/G stem-loop), while ADAR1 edits more promiscuously at several other adenosines in the double-stranded stem. The immediate structure surrounding the editing site is important. A purine opposite to the editing site has a negative effect on both selectivity and efficiency of editing. More distant internal loops in the substrate have minor effects on site selectivity, while efficiency of editing is influenced. Changes in the RNA structure that affected editing do not alter the binding abilities of ADAR2. Binding and catalysis are independent events | Rattus norvegicus | hypoxanthine in double-stranded RNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAR1 | - |
Rattus norvegicus |
ADAR2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |