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Literature summary for 3.5.4.37 extracted from

  • Wang, Q.
    RNA editing catalyzed by ADAR1 and its function in mammalian cells (2011), Biochemistry (Moscow), 76, 900-911.
    View publication on PubMed
Search for more literature for 3.5.4.37

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol two major isoforms of ADAR1, P150 and P110, named following their molecular weights, are yielded by different RNA splicings. The 150 kDa isoform, translated from exon 1a, is the full length protein that is mainly distributed in the cytosol. The 110 kDa isoform, coded by other alternative first exons and lacking the Z-DNA binding domains, is mainly located in the cell nucleus Mus musculus 5829
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nucleus two major isoforms of ADAR1, P150 and P110, named following their molecular weights, are yielded by different RNA splicings. The 150 kDa isoform, translated from exon 1a, is the full length protein that is mainly distributed in the cytosol. The 110 kDa isoform, coded by other alternative first exons and lacking the Z-DNA binding domains, is mainly located in the cell nucleus Mus musculus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine in double-stranded RNA + H2O Mus musculus
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 hypoxanthine in double-stranded RNA + NH3
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine in double-stranded RNA + H2O
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 Mus musculus hypoxanthine in double-stranded RNA + NH3
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 ?
adenine in double-stranded RNA + H2O ADAR1 specifically or preferentially edits 5HT2CR A and B sites Mus musculus hypoxanthine in double-stranded RNA + NH3
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 ?

Synonyms

Synonyms Comment Organism
ADAR1 two major isoforms of ADAR1, P150 and P110, named following their molecular weights, are yielded by different RNA splicings. The 150 kDa isoform, translated from exon 1a, is the full length protein that is mainly distributed in the cytosol. The 110 kDa isoform, coded by other alternative first exons and lacking the Z-DNA binding domains, is mainly located in the cell nucleus Mus musculus

Expression

Organism Comment Expression
Mus musculus isoform P110 is constitutively expressed in cells. In early mouse embryos, isoform P110 is expressed on day 10.5, but P150 was not expressed until day 15 up

General Information

General Information Comment Organism
malfunction ADAR1 knockout embryos die at day 11.5 to 12. ADAR1 is not completely necessary for cell survival because some cells survive without ADAR1. ADAR1 is dispensable in pluripotent cells for their survival and proliferation Mus musculus