Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-dimethylamino-6-hydroxypurine | promotes GDA activity when guanine is added | Rattus norvegicus | |
2-dimethylamino-6-hydroxypurine | promotes GDA activity when guanine is added | Oryctolagus cuniculus |
Application | Comment | Organism |
---|---|---|
medicine | GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders | Rattus norvegicus |
medicine | GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders | Oryctolagus cuniculus |
medicine | GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-diaminopurine | - |
Homo sapiens | |
2,6-diaminopurine | - |
Oryctolagus cuniculus | |
2,6-diaminopurine | - |
Rattus norvegicus | |
5-amino-4-imidazole carboxamide | - |
Homo sapiens | |
5-amino-4-imidazole carboxamide | - |
Oryctolagus cuniculus | |
5-amino-4-imidazole carboxamide | - |
Rattus norvegicus | |
7-methylguanine | - |
Homo sapiens | |
7-methylguanine | - |
Oryctolagus cuniculus | |
7-methylguanine | - |
Rattus norvegicus | |
Caffeine | - |
Homo sapiens | |
Caffeine | - |
Oryctolagus cuniculus | |
Caffeine | - |
Rattus norvegicus | |
N-2-acetylguanine | - |
Homo sapiens | |
N-2-acetylguanine | - |
Oryctolagus cuniculus | |
N-2-acetylguanine | - |
Rattus norvegicus | |
uric acid | - |
Homo sapiens | |
uric acid | - |
Oryctolagus cuniculus | |
uric acid | - |
Rattus norvegicus | |
xanthine | - |
Homo sapiens | |
xanthine | - |
Oryctolagus cuniculus | |
xanthine | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01121 | - |
guanine | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains zinc | Rattus norvegicus | |
Zn2+ | contains zinc | Oryctolagus cuniculus | |
Zn2+ | contains zinc | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y2T3 | - |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
? | |
guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
? | |
guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cypin | - |
Rattus norvegicus |
cypin | - |
Oryctolagus cuniculus |
cypin | - |
Homo sapiens |
GDA | - |
Rattus norvegicus |
GDA | - |
Oryctolagus cuniculus |
GDA | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00188 | - |
2,6-diaminopurine | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus | |
0.00196 | - |
xanthine | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus | |
0.00344 | - |
N-2-acetylguanine | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus | |
0.00434 | - |
uric acid | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus | |
0.00444 | - |
5-amino-4-imidazole carboxamide | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus | |
0.00555 | - |
7-methylguanine | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus | |
0.0102 | - |
Caffeine | in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C | Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
physiological function | GDA (cypin) mediates microtubule assembly | Rattus norvegicus |
physiological function | GDA (cypin) mediates microtubule assembly | Oryctolagus cuniculus |
physiological function | GDA (cypin) mediates microtubule assembly | Homo sapiens |