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Literature summary for 3.5.4.3 extracted from

  • Fernandez, J.R.; Sweet, E.S.; Welsh, W.J.; Firestein, B.L.
    Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine (2010), Bioorg. Med. Chem., 18, 6748-6755.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.3

Activating Compound

Activating Compound Comment Organism Structure
2-dimethylamino-6-hydroxypurine promotes GDA activity when guanine is added Rattus norvegicus
2-dimethylamino-6-hydroxypurine promotes GDA activity when guanine is added Oryctolagus cuniculus

Application

Application Comment Organism
medicine GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders Rattus norvegicus
medicine GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders Oryctolagus cuniculus
medicine GDA is an attractive and potential drug target for treatment of both liver diseases and cognitive disorders Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,6-diaminopurine
-
 Homo sapiens
2,6-diaminopurine
-
 Oryctolagus cuniculus
2,6-diaminopurine
-
 Rattus norvegicus
5-amino-4-imidazole carboxamide
-
 Homo sapiens
5-amino-4-imidazole carboxamide
-
 Oryctolagus cuniculus
5-amino-4-imidazole carboxamide
-
 Rattus norvegicus
7-methylguanine
-
 Homo sapiens
7-methylguanine
-
 Oryctolagus cuniculus
7-methylguanine
-
 Rattus norvegicus
Caffeine
-
 Homo sapiens
Caffeine
-
 Oryctolagus cuniculus
Caffeine
-
 Rattus norvegicus
N-2-acetylguanine
-
 Homo sapiens
N-2-acetylguanine
-
 Oryctolagus cuniculus
N-2-acetylguanine
-
 Rattus norvegicus
uric acid
-
 Homo sapiens
uric acid
-
 Oryctolagus cuniculus
uric acid
-
 Rattus norvegicus
xanthine
-
 Homo sapiens
xanthine
-
 Oryctolagus cuniculus
xanthine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01121
-
 guanine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Rattus norvegicus
Zn2+ contains zinc Oryctolagus cuniculus
Zn2+ contains zinc Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y2T3
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + H2O
-
 Rattus norvegicus xanthine + NH3
-
 ?
guanine + H2O
-
 Oryctolagus cuniculus xanthine + NH3
-
 ?
guanine + H2O
-
 Homo sapiens xanthine + NH3
-
 ?

Synonyms

Synonyms Comment Organism
cypin
-
 Rattus norvegicus
cypin
-
 Oryctolagus cuniculus
cypin
-
 Homo sapiens
GDA
-
 Rattus norvegicus
GDA
-
 Oryctolagus cuniculus
GDA
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00188
-
 2,6-diaminopurine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
0.00196
-
 xanthine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
0.00344
-
 N-2-acetylguanine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
0.00434
-
 uric acid in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
0.00444
-
 5-amino-4-imidazole carboxamide in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
0.00555
-
 7-methylguanine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus
0.0102
-
 Caffeine in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C Oryctolagus cuniculus

General Information

General Information Comment Organism
physiological function GDA (cypin) mediates microtubule assembly Rattus norvegicus
physiological function GDA (cypin) mediates microtubule assembly Oryctolagus cuniculus
physiological function GDA (cypin) mediates microtubule assembly Homo sapiens