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Literature summary for 3.5.4.3 extracted from
- Purification and properties of pig brain guanine deaminase (1978), Biochim. Biophys. Acta, 526, 235-246.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.011 | - |
guanine | - |
Sus sp. |  |
| 0.33 | - |
8-Azaguanine | - |
Sus sp. | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
2 * 50000, SDS-PAGE | Mus musculus |
| 50000 | - |
2 * 50000, SDS-PAGE | Oryctolagus cuniculus |
| 50000 | - |
2 * 50000, SDS-PAGE | Sus sp. |
| 55000 | - |
- |
Rattus norvegicus |
| 55000 | - |
- |
Oryctolagus cuniculus |
| 110000 | - |
- |
Rattus norvegicus |
| 110000 | - |
- |
Oryctolagus cuniculus |
| 110000 | - |
brain, gel filtration | Sus sp. |
| 170000 | - |
- |
Oryctolagus cuniculus |
| 207000 | - |
- |
Oryctolagus cuniculus |
| 525000 | - |
- |
Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | Mus musculus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Oryctolagus cuniculus | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Platyrrhini | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Ovis ammon | - |
xanthine + NH3 | - |
? | |
| guanine + H2O | Sus sp. | - |
xanthine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Ovis ammon | - |
sheep | - |
| Platyrrhini | - |
- |
- |
| Rattus norvegicus | - |
rat | - |
| Sus sp. | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Oryctolagus cuniculus | - |
| brain | - |
Sus sp. | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 0.1 M phosphate buffer, 2 mM 2-mercaptoethanol, pH 7.5, stable for at least 3 months | Sus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-thioguanine + H2O | - |
Oryctolagus cuniculus | 6-thioxanthine + NH3 | - |
? | |
| 6-thioguanine + H2O | - |
Sus sp. | 6-thioxanthine + NH3 | - |
? | |
| 8-azaguanine + H2O | - |
Sus sp. | 8-azaxanthine + NH3 | - |
? | |
| guanine + H2O | - |
Mus musculus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Platyrrhini | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Ovis ammon | xanthine + NH3 | - |
? | |
| guanine + H2O | - |
Sus sp. | xanthine + NH3 | - |
? | |
| additional information | high specificity towards guanine, 2-amino-6-chloropurine, 8-bromoguanine, 7-methylguanine, thioguanine, guanosine, guanosine 5'-monophosphate, guanilic acid, adenosine and 2-aminopurine are no substrates | Sus sp. | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Rattus norvegicus |
| dimer | 2 * 50000, SDS-PAGE | Mus musculus |
| dimer | 2 * 50000, SDS-PAGE | Oryctolagus cuniculus |
| dimer | 2 * 50000, SDS-PAGE | Sus sp. |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 10 | - |
Sus sp. |
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