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Literature summary for 3.5.4.3 extracted from
- Guanase from human liver - purification and characterization (1980), Adv. Exp. Med. Biol., 122B, 183-188.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0026 | - |
guanine | isoenzyme B | Homo sapiens |  |
| 0.0056 | - |
guanine | isoenzyme A | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 100000 | - |
2 isoenzymes called A and B | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | Mus musculus | - |
xanthine + NH3 | - |
ir | |
| guanine + H2O | Homo sapiens | - |
xanthine + NH3 | - |
ir | |
| guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Mus musculus | - |
mouse | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| brain | 2 isoenzymes | Mus musculus | - |
| brain | 2 isoenzymes | Rattus norvegicus | - |
| epididymis | - |
Homo sapiens | - |
| erythrocyte | 2 isoenzymes | Mus musculus | - |
| erythrocyte | 2 isoenzymes | Rattus norvegicus | - |
| gut | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | 2 isoenzymes | Rattus norvegicus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| muscle | - |
Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| thyroid gland | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 21.7 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + H2O | - |
Mus musculus | xanthine + NH3 | - |
ir | |
| guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
ir | |
| guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
ir | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
isoenzyme A | Homo sapiens |
| 9 | - |
isoenzyme B | Homo sapiens |
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