BRENDA - Enzyme Database show
show all sequences of 3.5.4.3

Purification and characterization of guanine aminohydrolase from human liver

Kimm, S.W.; Park, J.B.; Lee, I.S.; Korean J. Biochem. 17, 139-148 (1985)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
5-aminoimidazole-4-carboxamide
29% inhibition
Homo sapiens
5-aminoimidazole-4-carboxamide
-
Oryctolagus cuniculus
5-aminoimidazole-4-carboxamide
-
Rattus norvegicus
adenine
-
Homo sapiens
adenosine
-
Homo sapiens
hypoxanthine
slight inhibition of 8%
Homo sapiens
Inosine
slight inhibition of 5%
Homo sapiens
p-hydroxymercuribenzoate
noncompetitive inhibitor, 0.1 mM, 37C, rapid inactivation
Homo sapiens
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate
-
Rattus norvegicus
xanthine
-
Homo sapiens
Xanthosine
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0074
-
guanine
at pH 8
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
55000
-
-
Homo sapiens
55000
-
liver, single polypeptide chain, gel filtration
Oryctolagus cuniculus
55000
-
liver, single polypeptide chain, gel filtration
Rattus norvegicus
100000
-
gel filtration
Homo sapiens
100000
-
-
Oryctolagus cuniculus
110000
-
liver, gel filtration
Homo sapiens
110000
-
liver, gel filtration
Oryctolagus cuniculus
110000
-
-
Rattus norvegicus
220000
-
gel filtration without mercaptoethanol
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
guanine + H2O
Homo sapiens
-
xanthine + NH3
-
-
ir
guanine + H2O
Rattus norvegicus
-
xanthine + NH3
-
-
ir
guanine + H2O
Oryctolagus cuniculus
-
xanthine + NH3
-
-
ir
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
human
-
Oryctolagus cuniculus
-
rabbit
-
Rattus norvegicus
-
rat
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
-
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Oryctolagus cuniculus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
8.61
-
-
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
8-azaguanine + H2O
-
209585
Rattus norvegicus
8-azaxanthine + NH3
-
-
-
?
8-azaguanine + H2O
-
209585
Oryctolagus cuniculus
8-azaxanthine + NH3
-
-
-
?
8-azaguanine + H2O
high substrate specificity, only 60% of the reaction rate with the natural substrate guanine
209585
Homo sapiens
8-azaxanthine + NH3
-
-
-
?
adenine + H2O
-
209585
Homo sapiens
allopurinol + NH3
-
-
-
?
adenosine + H2O
-
209585
Homo sapiens
inosine + NH3
-
-
-
?
AMP + H2O
-
209585
Homo sapiens
IMP + NH3
-
-
-
?
GMP + H2O
-
209585
Homo sapiens
XMP + NH3
-
-
-
?
guanine + H2O
-
209585
Homo sapiens
xanthine + NH3
-
-
-
ir
guanine + H2O
-
209585
Rattus norvegicus
xanthine + NH3
-
-
-
ir
guanine + H2O
-
209585
Oryctolagus cuniculus
xanthine + NH3
-
-
-
ir
guanosine + H2O
-
209585
Homo sapiens
xanthosine + NH3
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
-
Oryctolagus cuniculus
dimer
2 * 55000, 2 or 3 isoenzymes, polymeric nature, enzyme exists as monomer, dimer or tetramer
Rattus norvegicus
dimer
-
Homo sapiens
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
60
-
50% activity lost during 30 min incubation, after 60 min 40% activity remains
Homo sapiens
60
-
30 min incubation, liver enzyme completely inactivated
Oryctolagus cuniculus
60
-
30 min incubation, liver enzyme completely inactivated
Rattus norvegicus
65
-
activity completely lost after 30 min incubation
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
-
Oryctolagus cuniculus
7.5
9.5
beyond pH 9.5 activity decreases abruptly
Homo sapiens
7.5
9.5
-
Oryctolagus cuniculus
7.5
9.5
-
Rattus norvegicus
8
-
-
Homo sapiens
8
-
-
Oryctolagus cuniculus
8
-
-
Rattus norvegicus
8.5
-
-
Oryctolagus cuniculus
8.5
-
-
Rattus norvegicus
8.6
-
-
Oryctolagus cuniculus
9
-
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
5-aminoimidazole-4-carboxamide
29% inhibition
Homo sapiens
5-aminoimidazole-4-carboxamide
-
Oryctolagus cuniculus
5-aminoimidazole-4-carboxamide
-
Rattus norvegicus
adenine
-
Homo sapiens
adenosine
-
Homo sapiens
hypoxanthine
slight inhibition of 8%
Homo sapiens
Inosine
slight inhibition of 5%
Homo sapiens
p-hydroxymercuribenzoate
noncompetitive inhibitor, 0.1 mM, 37C, rapid inactivation
Homo sapiens
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate
-
Rattus norvegicus
xanthine
-
Homo sapiens
Xanthosine
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0074
-
guanine
at pH 8
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Homo sapiens
5829
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
55000
-
-
Homo sapiens
55000
-
liver, single polypeptide chain, gel filtration
Oryctolagus cuniculus
55000
-
liver, single polypeptide chain, gel filtration
Rattus norvegicus
100000
-
gel filtration
Homo sapiens
100000
-
-
Oryctolagus cuniculus
110000
-
liver, gel filtration
Homo sapiens
110000
-
liver, gel filtration
Oryctolagus cuniculus
110000
-
-
Rattus norvegicus
220000
-
gel filtration without mercaptoethanol
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
guanine + H2O
Homo sapiens
-
xanthine + NH3
-
-
ir
guanine + H2O
Rattus norvegicus
-
xanthine + NH3
-
-
ir
guanine + H2O
Oryctolagus cuniculus
-
xanthine + NH3
-
-
ir
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
-
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Oryctolagus cuniculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
8.61
-
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
8-azaguanine + H2O
-
209585
Rattus norvegicus
8-azaxanthine + NH3
-
-
-
?
8-azaguanine + H2O
-
209585
Oryctolagus cuniculus
8-azaxanthine + NH3
-
-
-
?
8-azaguanine + H2O
high substrate specificity, only 60% of the reaction rate with the natural substrate guanine
209585
Homo sapiens
8-azaxanthine + NH3
-
-
-
?
adenine + H2O
-
209585
Homo sapiens
allopurinol + NH3
-
-
-
?
adenosine + H2O
-
209585
Homo sapiens
inosine + NH3
-
-
-
?
AMP + H2O
-
209585
Homo sapiens
IMP + NH3
-
-
-
?
GMP + H2O
-
209585
Homo sapiens
XMP + NH3
-
-
-
?
guanine + H2O
-
209585
Homo sapiens
xanthine + NH3
-
-
-
ir
guanine + H2O
-
209585
Rattus norvegicus
xanthine + NH3
-
-
-
ir
guanine + H2O
-
209585
Oryctolagus cuniculus
xanthine + NH3
-
-
-
ir
guanosine + H2O
-
209585
Homo sapiens
xanthosine + NH3
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Oryctolagus cuniculus
dimer
2 * 55000, 2 or 3 isoenzymes, polymeric nature, enzyme exists as monomer, dimer or tetramer
Rattus norvegicus
dimer
-
Homo sapiens
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
60
-
50% activity lost during 30 min incubation, after 60 min 40% activity remains
Homo sapiens
60
-
30 min incubation, liver enzyme completely inactivated
Oryctolagus cuniculus
60
-
30 min incubation, liver enzyme completely inactivated
Rattus norvegicus
65
-
activity completely lost after 30 min incubation
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
-
-
Oryctolagus cuniculus
7.5
9.5
beyond pH 9.5 activity decreases abruptly
Homo sapiens
7.5
9.5
-
Oryctolagus cuniculus
7.5
9.5
-
Rattus norvegicus
8
-
-
Homo sapiens
8
-
-
Oryctolagus cuniculus
8
-
-
Rattus norvegicus
8.5
-
-
Oryctolagus cuniculus
8.5
-
-
Rattus norvegicus
8.6
-
-
Oryctolagus cuniculus
9
-
-
Homo sapiens
Other publictions for EC 3.5.4.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734510
Trautwein-Schult
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2
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3
3
2
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1
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2
4
16
1
1
-
2
2
2
-
1
-
-
1
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-
-
1
-
-
-
-
-
1
-
2
2
3
3
2
-
-
-
1
-
-
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4
16
1
1
-
2
2
2
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1
1
1
-
-
1
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-
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52
3512-3522
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-
-
-
1
3
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-
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1
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2
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2
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2
1
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1
3
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1
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2
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2
1
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-
-
-
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-
-
-
-
-
-
-
1
1
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Analogs of iso-azepinomycin as ...
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21
4893-4903
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-
-
-
-
-
13
-
-
-
-
1
-
2
-
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-
1
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1
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11
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13
11
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1
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-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733480
Chakraborty
Investigations into specificit ...
Oryctolagus cuniculus
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22
7214-7218
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-
-
-
-
-
-
3
-
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-
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1
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2
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1
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1
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3
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3
3
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1
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1
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1
-
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-
-
-
-
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-
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-
-
-
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719723
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Klebsiella pneumoniae
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193
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1
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1
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2
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1
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1
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1
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1
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1
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
711469
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Bioorg. Med. Chem.
18
6748-6755
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2
3
-
-
-
-
21
1
-
3
-
-
-
5
-
-
1
-
-
1
-
-
3
-
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-
-
-
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7
-
-
2
3
-
-
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21
7
1
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3
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1
-
1
-
-
3
-
-
-
-
-
-
-
-
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-
3
3
-
-
-
712293
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192
1106-1112
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-
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1
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-
-
-
-
-
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72
-
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2
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18
-
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1
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2
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18
-
-
-
-
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4
4
-
-
-
712380
Kim
Guanine deaminase functions as ...
Drosophila melanogaster, Drosophila melanogaster Oregon-R
J. Biol. Chem.
284
23426-23435
2009
-
-
1
-
-
-
9
2
-
-
1
-
-
5
-
-
1
-
-
1
2
-
10
1
1
-
-
2
1
-
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-
-
1
-
-
-
1
-
-
-
-
-
9
-
2
-
-
1
-
-
-
-
1
-
1
2
-
10
1
1
-
-
2
1
-
-
1
-
1
1
-
2
2
713411
Murphy
Alteration of enzyme specifici ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
106
9215-9220
2009
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-
1
-
-
-
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1
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2
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1
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2
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1
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1
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1
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2
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689944
Fernandez
Structural characterization of ...
Rattus norvegicus
Proteins
70
873-881
2008
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1
-
7
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1
1
-
1
-
2
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-
3
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2
1
1
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1
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1
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7
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1
1
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1
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3
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2
1
1
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1
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697984
Medici
Arthrobacter oxydans as a bioc ...
Pseudarthrobacter oxydans
FEMS Microbiol. Lett.
289
20-26
2008
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1
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1
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4
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1
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4
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688614
Yao
Catalytic mechanism of guanine ...
Bacillus subtilis
J. Phys. Chem. B
111
4200-4210
2007
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209539
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12
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11
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11
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209586
Gupta
Isolation and characterization ...
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23
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26
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1
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10
5
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6
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7
1
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209587
Pugh
Studies of rabbit brain, intes ...
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31
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16
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1
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5
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5
1
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209588
Kim
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1
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11
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6
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12
5
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6
2
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1
1
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1
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Miyamoto
Guanine deaminase from rat bra ...
Rattus norvegicus, Rattus norvegicus Wistar, Sus sp.
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2
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3
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5
1
1
5
2
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1
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Kuzmits
Guanase from human liver - pur ...
Homo sapiens, Mus musculus, Rattus norvegicus
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22
1
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2
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Bergstrom
Characterization of purified g ...
Oryctolagus cuniculus
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194
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2
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2
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1
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1
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2
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Glantz
Guanine deaminase from rabbit ...
Oryctolagus cuniculus
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209593
Rossi
Purification and properties of ...
Mus musculus, Oryctolagus cuniculus, Ovis ammon, Platyrrhini, Rattus norvegicus, Sus sp.
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526
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1978
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209594
Fogle
Purification of rabbit liver g ...
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Lewis
Rabbit liver guanine deaminase ...
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