Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-aminoimidazole-4-carboxamide | AICA, competitive inhibition | Homo sapiens | |
5-aminoimidazole-4-carboxamide | AICA, competitive inhibition | Oryctolagus cuniculus | |
5-aminoimidazole-4-carboxamide | AICA, competitive inhibition | Rattus norvegicus | |
F- | inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 | Homo sapiens | |
F- | inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 | Oryctolagus cuniculus | |
hypoxanthine | - |
Homo sapiens | |
Inosine | - |
Homo sapiens | |
p-hydroxymercuribenzoate | - |
Homo sapiens | |
p-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
Rose bengal | photo-oxidation, 0.00025% at acidic pH | Homo sapiens | |
Rose bengal | photo-oxidation, 0.00025% at acidic pH | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0074 | - |
guanine | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
SDS-PAGE | Homo sapiens |
55000 | - |
liver, single polypeptide chain, gel filtration | Rattus norvegicus |
55000 | - |
liver, single polypeptide chain, gel filtration | Oryctolagus cuniculus |
55000 | - |
2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups | Sus sp. |
110000 | - |
liver, gel filtration | Homo sapiens |
110000 | - |
liver, gel filtration | Oryctolagus cuniculus |
110000 | - |
lung | Rattus norvegicus |
110000 | - |
brain, gel filtration | Sus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + H2O | Homo sapiens | - |
xanthine + NH3 | - |
? | |
guanine + H2O | Rattus norvegicus | - |
xanthine + NH3 | - |
? | |
guanine + H2O | Oryctolagus cuniculus | - |
xanthine + NH3 | - |
? | |
guanine + H2O | Sus sp. | - |
xanthine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Oryctolagus cuniculus | - |
rabbit | - |
Rattus norvegicus | - |
rat | - |
Sus sp. | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Oryctolagus cuniculus | - |
brain | - |
Sus sp. | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
22.1 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + H2O | - |
Homo sapiens | xanthine + NH3 | - |
? | |
guanine + H2O | - |
Rattus norvegicus | xanthine + NH3 | - |
? | |
guanine + H2O | - |
Oryctolagus cuniculus | xanthine + NH3 | - |
? | |
guanine + H2O | - |
Sus sp. | xanthine + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Rattus norvegicus |
dimer | 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups | Homo sapiens |
dimer | 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups | Oryctolagus cuniculus |
dimer | 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups | Sus sp. |
monomer | - |
Oryctolagus cuniculus |
monomer | liver enzyme | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
GAH | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9.5 | - |
Homo sapiens |
7.5 | 9.5 | - |
Rattus norvegicus |
7.5 | 9.5 | - |
Oryctolagus cuniculus |
9 | - |
- |
Homo sapiens |
9 | - |
- |
Sus sp. |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 10.5 | - |
Homo sapiens |