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Literature summary for 3.5.4.3 extracted from

  • Kimm, S.W.; Park, J.B.; Kim, H.L.
    The physicochemical properties of guanine aminohydrolase purified from human liver (1987), Korean J. Biochem., 19, 39-46.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
5-aminoimidazole-4-carboxamide AICA, competitive inhibition Homo sapiens
5-aminoimidazole-4-carboxamide AICA, competitive inhibition Oryctolagus cuniculus
5-aminoimidazole-4-carboxamide AICA, competitive inhibition Rattus norvegicus
F- inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 Homo sapiens
F- inhibition decreases as pH increases, 50% activity was inhibited at pH 7.5, most of activity lost at pH 6.5 Oryctolagus cuniculus
hypoxanthine
-
Homo sapiens
Inosine
-
Homo sapiens
p-hydroxymercuribenzoate
-
Homo sapiens
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
p-hydroxymercuribenzoate
-
Rattus norvegicus
Rose bengal photo-oxidation, 0.00025% at acidic pH Homo sapiens
Rose bengal photo-oxidation, 0.00025% at acidic pH Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0074
-
guanine
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
SDS-PAGE Homo sapiens
55000
-
liver, single polypeptide chain, gel filtration Rattus norvegicus
55000
-
liver, single polypeptide chain, gel filtration Oryctolagus cuniculus
55000
-
2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
110000
-
liver, gel filtration Homo sapiens
110000
-
liver, gel filtration Oryctolagus cuniculus
110000
-
lung Rattus norvegicus
110000
-
brain, gel filtration Sus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
guanine + H2O Homo sapiens
-
xanthine + NH3
-
?
guanine + H2O Rattus norvegicus
-
xanthine + NH3
-
?
guanine + H2O Oryctolagus cuniculus
-
xanthine + NH3
-
?
guanine + H2O Sus sp.
-
xanthine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Oryctolagus cuniculus
-
rabbit
-
Rattus norvegicus
-
rat
-
Sus sp.
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Rattus norvegicus
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
brain
-
Oryctolagus cuniculus
-
brain
-
Sus sp.
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
lung
-
Homo sapiens
-
lung
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
22.1
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + H2O
-
Homo sapiens xanthine + NH3
-
?
guanine + H2O
-
Rattus norvegicus xanthine + NH3
-
?
guanine + H2O
-
Oryctolagus cuniculus xanthine + NH3
-
?
guanine + H2O
-
Sus sp. xanthine + NH3
-
?

Subunits

Subunits Comment Organism
dimer
-
Rattus norvegicus
dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Homo sapiens
dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Oryctolagus cuniculus
dimer 2 * 55000, can be converted into monomeric form by addition of sulfhydryl groups Sus sp.
monomer
-
Oryctolagus cuniculus
monomer liver enzyme Rattus norvegicus

Synonyms

Synonyms Comment Organism
GAH
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 9.5
-
Homo sapiens
7.5 9.5
-
Rattus norvegicus
7.5 9.5
-
Oryctolagus cuniculus
9
-
-
Homo sapiens
9
-
-
Sus sp.

pH Range

pH Minimum pH Maximum Comment Organism
5 10.5
-
Homo sapiens