Literature summary for 3.5.4.25 extracted from

Blau, N.; Niederwieser, A.
GTP-cyclohydrolases: a review (1985), J. Clin. Chem. Clin. Biochem., 23, 169-176.

Search for more literature for 3.5.4.25

Inhibitors

Inhibitors	Comment	Organism	Structure
Cu2+	-	Meyerozyma guilliermondii
diphosphate	-	Escherichia coli
diphosphate	-	Meyerozyma guilliermondii
phosphate	-	Meyerozyma guilliermondii
Zn2+	-	Meyerozyma guilliermondii

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.22	-	GTP	-	Meyerozyma guilliermondii
0.41	-	GTP	-	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	Mg2+ dependent	Escherichia coli
Mg2+	Mg2+ dependent	Meyerozyma guilliermondii

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
44000	-	-	Escherichia coli
170000	-	gel filtration	Meyerozyma guilliermondii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Escherichia coli	-	formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate	-	?
GTP + H2O	Meyerozyma guilliermondii	-	formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Meyerozyma guilliermondii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Escherichia coli	formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate	-	?
GTP + H2O	-	Meyerozyma guilliermondii	formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.2	-	-	Meyerozyma guilliermondii
8.5	-	-	Escherichia coli

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Release 2023.1 (January 2023)