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Literature summary for 3.5.4.12 extracted from

  • Maley, F.; Belfort, M.; Maley, G.
    Probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase (1984), Adv. Enzyme Regul., 22, 413-430.
    View publication on PubMed
Search for more literature for 3.5.4.12

Activating Compound

Activating Compound Comment Organism Structure
5-hydroxymethyl-dCTP natural positive allosteric effector, enzyme is much more effectively regulated by its natural effector, 5-hydroxymethyl-dCTP, than by dCTP, binding of 5-hydroxymethyl-dCTP is much more pH dependent than dCTP Escherichia phage T2
dCTP positive allosteric effector Gallus gallus
dCTP positive allosteric effector Escherichia phage T2

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Escherichia phage T2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Gallus gallus
additional information
-
 additional information
-
 Escherichia phage T2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCMP + H2O Gallus gallus enzyme involved in formation of dTMP dUMP + NH3
-
 ?
dCMP + H2O Escherichia phage T2 enzyme involved in formation of dTMP dUMP + NH3
-
 ?
dCMP + H2O Gallus gallus enzyme within pyrimidine deoxynucleotide pathway dUMP + NH3
-
 ?
dCMP + H2O Escherichia phage T2 enzyme within pyrimidine deoxynucleotide pathway dUMP + NH3
-
 ?
dCMP + H2O Gallus gallus enzyme plays an important if not rate controlling step in cell division dUMP + NH3
-
 ?
dCMP + H2O Escherichia phage T2 enzyme plays an important if not rate controlling step in cell division dUMP + NH3
-
 ?
dCMP + H2O Gallus gallus regulating dTMP for DNA synthesis dUMP + NH3
-
 ?
dCMP + H2O Escherichia phage T2 regulating dTMP for DNA synthesis dUMP + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia phage T2
-
 T2-phage infected Escherichia coli
-
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
T2-phage infected Escherichia coli Escherichia phage T2

Reaction

Reaction Comment Organism Reaction ID
dCMP + H2O = dUMP + NH3 mechanism Escherichia phage T2
a
dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Gallus gallus
a
dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Escherichia phage T2
a

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCMP + H2O
-
 Gallus gallus dUMP + NH3
-
 ?
dCMP + H2O
-
 Escherichia phage T2 dUMP + NH3
-
 ?
dCMP + H2O enzyme involved in formation of dTMP Gallus gallus dUMP + NH3
-
 ?
dCMP + H2O enzyme involved in formation of dTMP Escherichia phage T2 dUMP + NH3
-
 ?
dCMP + H2O enzyme within pyrimidine deoxynucleotide pathway Gallus gallus dUMP + NH3
-
 ?
dCMP + H2O enzyme within pyrimidine deoxynucleotide pathway Escherichia phage T2 dUMP + NH3
-
 ?
dCMP + H2O enzyme plays an important if not rate controlling step in cell division Gallus gallus dUMP + NH3
-
 ?
dCMP + H2O enzyme plays an important if not rate controlling step in cell division Escherichia phage T2 dUMP + NH3
-
 ?
dCMP + H2O regulating dTMP for DNA synthesis Gallus gallus dUMP + NH3
-
 ?
dCMP + H2O regulating dTMP for DNA synthesis Escherichia phage T2 dUMP + NH3
-
 ?

Subunits

Subunits Comment Organism
hexamer 6 identical subunits Gallus gallus
hexamer 6 identical subunits Escherichia phage T2

Synonyms

Synonyms Comment Organism
T2-dCMP deaminase T2-phage infected Escherichia phage T2
T2-deoxycytidylate deaminase T2-phage infected Escherichia phage T2
T2-phage deoxycytidylate deaminase T2-phage infected Escherichia phage T2