Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-hydroxypteridin-6-carboxylic acid | - |
Alcaligenes metalcaligenes | |
KF | - |
Alcaligenes metalcaligenes | |
NaF | - |
Alcaligenes metalcaligenes | |
p-chloromercuribenzoate | - |
Alcaligenes metalcaligenes |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Alcaligenes metalcaligenes | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Alcaligenes metalcaligenes |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-4-hydroxypteridine + H2O | i.e. pterin | Alcaligenes metalcaligenes | 2,4-dihydroxypteridine + NH3 | i.e. lumazine | ir | |
additional information | Only pteridines possessing the pterin structure (i.e. the 2-amino and 4-hydroxyl functional groups) are deaminated. The nature of the substitution at carbon 6 is relatively unimportant. However, an hydroxyl group at this position results in an inactive substance. Carbon 7 must be unsubstituted, since blocking of this position by a methyl or carboxyl function destroys the ability of the pterin to serve as a substrate. An N-5-formylated and reduced pterin is not deaminated | Alcaligenes metalcaligenes | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.3 | 6.7 | although the reaction proceeds in the complete absence of phosphate, the rate of deamination is slightly faster in phosphate than in Tris buffer | Alcaligenes metalcaligenes |