Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | Q95QQ4 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
AICAR-transformylase/IMP cyclohydrolase | - |
Caenorhabditis elegans |
atic-1 | - |
Caenorhabditis elegans |
Organism | Comment | Expression |
---|---|---|
Caenorhabditis elegans | high glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine de novo synthesis. High glucose up-regulates the expression and activity of the enzyme and increases the levels of reactive oxygen species and methylglyoxal-derived advanced glycation end products. Overexpression of the enzyme (atic-1) decreases the lifespan and head motility and increases neuronal damage under both standard and high glucose conditions. Inhibition of atic-1 expression, by RNAi, under high glucose is associated with increased lifespan and head motility and reduced neuronal damage, reactive oxygen species, and methylglyoxal-derived advanced glycation end product accumulation. The enzyme (atic-1) is involved in glucotoxic effects under high glucose conditions, either by blocked atic-1 expression or viainduction of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and AMP-activated kinase (AMPK) induction | Caenorhabditis elegans |